Sökning: "Adapt"
Visar resultat 1 - 5 av 1199 avhandlingar innehållade ordet Adapt.
1. Development of ADAPT-based tracers for radionuclide molecular imaging of cancer
Sammanfattning : ABD-Derived Affinity Proteins (ADAPTs) is a novel class of small engineered scaffold proteins based on albumin-binding domain (ABD) of streptococcal protein G. High affinity ADAPT binders against various therapeutic targets can be selected. LÄS MER
2. The ADAPT scaffold as a tool for diagnostic imaging and targeted therapy
Sammanfattning : Molecular recognition, or the specific interactions between a protein and its ligand, is central to biology and a key factor for many different clinical and technical applications. Despite antibodies being only one of many different affinity proteins, it has by far been the most successful. LÄS MER
3. Bifunctional ADAPTs: Opportunity for serological Half-life extension and Targeted therapy
Sammanfattning : Small engineered scaffold proteins (ESPs) gain more and more popularity as biological drugs, due to their specificity and applicability in diagnostics and therapy. Thanks to their high stability, low immunogenicity and low production cost, they present themselves as a promising alternative to the market-leading antibodies. LÄS MER
4. Tumor targeted delivery of cytotoxic payloads using affibody molecules and ABD-derived affinity proteins
Sammanfattning : Cancer treatment cost billions of dollars every year, but the mortality rate is still high. An ideal treatment is the so-called “magic bullets” that recognize and kill tumor cells while leaving normal cells untouched. LÄS MER
5. Engineering of alternative scaffold derived drug conjugates and fusion-toxins for targeted cancer therapy
Sammanfattning : Cancer is a major health problem, with premature death for many patients, and with a high monetary cost to society. The disease is complex to treat due to the many different types, but also because the disease-causing cells, that needs to be removed, are very similar to the normal cells. LÄS MER