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1. 1. Targeting insulin-like growth factor-1 receptor in cancer

   Författare :Ada Girnita; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :IGF1; IGF-1R; MDM2; p53; PPP; Tamoxifen; tyrosine kinase inhibitors; ubiquitin;

   Sammanfattning : Cancer is a multi-step process where the accumulation of several genetic and epigenetic alterations drives the transformation of a normal cell to a malignant cell, skipping the normal control of defense, repair and apoptosis. During the selection process towards a malignant phenotype, the transforming cells make use of normal (physiological) extracellular signaling pathways to create growth advantage over normal cells. LÄS MER