Sökning: "Acute lymphoblastic leukemia ALL"

Visar resultat 16 - 20 av 73 avhandlingar innehållade orden Acute lymphoblastic leukemia ALL.

1. 16. Gene Expression Studies of Hematologic Malignacies

   Författare :Anna Andersson; Avdelningen för klinisk genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Haematology; cancer; onkologi; Cytologi; oncology; Cytology; acute myeloid leukemia; acute lymphoblastic leukemia; normal hematopoietic cells; cDNA microarray; gene expression profiling; hematopoiesis; pediatric leukemia; fusion gene; Pediatrics; Pediatri; Clinical genetics; Klinisk genetik; cancerology; Hematologi; extracellulära vätskor;

   Sammanfattning : The general aim of this thesis was to characterize hematologic malignancies using gene expression profiling in order to obtain an improved classification and to study deregulated transcriptional networks in leukemia. In the first study (Article I), the gene expression profiles of hematologic cell lines were analyzed to investigate whether such cell lines maintain expression profiles that are characteristic of their primary genetic changes. LÄS MER

3. 17. Vascular density and bone marrow fibrosis in childhood acute lymphoblastic leukemia

   Författare :Ulrika Norén Nyström; Anders Bergh; Erik Forestier; Göran Roos; Henrik Schrøder; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Childhood acute lymphoblastic leukemia; microvessel density; bone marrow fibrosis; in vitro drug resistance; minimal residual disease; outcome; Oncology; Onkologi;

   Sammanfattning : Background: In childhood acute lymphoblastic leukemia (ALL), the cure rate has now reached 80% in the western world. Even so, 15¬–20% will die from the disease or treatment-related causes, among them children who did not present any known unfavorable features at diagnosis. LÄS MER

4. 18. Optimizing Chemotherapy in Childhood Acute Myeloid Leukemia

   Författare :Josefine Palle; Gudmar Lönnerholm; Britt-Marie Frost; Rolf Larsson; Henrik Schröder; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; childhood; acute myeloid leukemia; drug resistance; pharmacokinetics; chromosomal abnormalities; Down syndrome; MLL-rearrangement; t 9; 11 ; Paediatric medicine; Pediatrisk medicin;

   Sammanfattning : Despite major advances in our understanding of the biology of childhood acute myeloid leukemia (AML) and the development of new cytotoxic drugs, the prognosis of long-term survival is still only 60-65 %.In the present research, we studied the pharmacokinetics of drugs used in the induction therapy of childhood AML and performed in vitro drug sensitivity testing of leukemic cells from children with AML. LÄS MER

5. 19. DNA methylation signatures in precursor lymphoid neoplasms : with focus on clinical implications & the biology behind

   Författare :Zahra Haider; Sofie Degerman; Magnus Hultdin; Göran Roos; Pieter van Vlierberghe; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Acute Lymphoblastic Leukemia; Lymphoma; T-ALL; BCP-ALL; T-LBL; DNA methylation; CIMP; Prognosis; TAL1; HOX.;

   Sammanfattning : Precursor lymphoid neoplasms, namely acute lymphoblastic leukemias (ALL) and lymphoblastic lymphomas (LBL), are characterized by an aggressive proliferation of malignant progenitor B- or T-cells. To improve risk classification at diagnosis, better prognostic and treatment stratifying biomarkers are needed. LÄS MER

7. 20. Studies of cerebral blood flow and cerebrospinal fluid in childhood acute lymphoblastic leukemia

   Författare :Gustaf Österlundh; Göteborgs universitet; []
   Nyckelord :childhood acute lymphoblastic leukemia; methotrexate; neurotoxicity; cerebral blood flow; single photon emission computed tomography; cerebrospinal fluid; neuron-specific enolase; glia fibrillary acidic protein; neurofilament; ascorbyl radical;

   Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and more than 80% of the patients are cured today. Treatment might cause side effects and central nervous system (CNS) irradiation has been replaced by systemic high-dose methotrexate (MTX) and intrathecal (IT) MTX due to the risk of late effects. LÄS MER