Sökning: "Ac-YVAD-cmk"

Hittade 2 avhandlingar innehållade ordet Ac-YVAD-cmk.

  1. 1. Apoptosis And Excitotoxicity In The Death of Cultured And Grafted Dopaminergic Neurones

    Detta är en avhandling från Department of Physiological Sciences, Lund University

    Författare :Gabriele Schierle; Lund University.; Lunds universitet.; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ac-YVAD-cmk; MK-801; flunarizine; N-methyl-D-aspartate; voltage-dependent calcium channels; Bcl-2; caspase; excitotoxicity; apoptosis; tyrosine hydroxylase; dopamine; Parkinson s disease; intracerebral transplantation; Poly ADP-ribose polymerase; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Over the past two decades, grafting of embryonic nigral tissue has developed into a feasible therapeutic strategy for Parkinson's disease (PD). It has become apparent that the degree of restoration of dopaminergic neurotransmission by the transplanted cells is highly correlated to the symptomatic relief. LÄS MER

  2. 2. Neuronal Cell Death and Restoration in the Basal Ganglia: Implications for Huntington's and Parkinson's diseases

    Detta är en avhandling från Wallenberg Neuroscience Center, BMC, Lund University

    Författare :Oskar Hansson; Lund University.; Lunds universitet.; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; basal ganglia; Parkinson s disease; Huntington s disease; neural transplantation; restoration; NMDA receptor; excitotoxicity; calcium; caspase; neuronal cell death; apoptosis; transgenic mouse; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Huntington's disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia and extensive striatal neuronal death. The mechanism through which the widely expressed mutant huntingtin mediates striatal neurotoxicity is unknown. Excitotoxicity, i.e. LÄS MER