Avancerad sökning

Visar resultat 1 - 5 av 547 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Limiting factors in ATP synthesis

    Författare :Tatiana Kramarova; Barbara Cannon; Sharon Ackerman; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ATP synthase; biosynthesis; assembly; uncoupling proteins; ATP ADP carrier; Physiology; Fysiologi;

    Sammanfattning : The aim of the present study was to investigate the biosynthesis of the ATP synthase in various tissues, and to test hypotheses about possible models of activation of several mitochondrial proteins, the ATP/ADP translocase and UCPs, that could utilize the proton gradient, thus bypassing the ATP synthase. We have examined the role of the expression of the P1 isoform of the c-Fo subunit in the biogenesis of ATP synthase in brown adipose tissue. LÄS MER

  3. 2. Role of extracellular ATP in immune mechanisms against infections

    Författare :Lalitha Tadala; Andrea Puhar; Sara I Wilson; Bernt Eric Uhlin; Mikael Sellin; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Extracellular ATP; invasive bacteria; Shigella; Listeria; plasma membrane ruffle; PIEZO1; infection; immune response; Hanta virus; molekylär cellbiologi; molecular cell biology;

    Sammanfattning : Inflammation is driven either by infection with pathogens or sterile stimuli, such as tissue damage or autoimmune diseases. Upon tissue damage, ATP is released passively from the dead or compromised cells. During stress, ATP can be secreted from the cells. Extracellular ATP (eATP) acts as an endogenous danger signal. LÄS MER

  4. 3. ATP Dynamics in Pancreatic α- and β-cells

    Författare :Jia Li; Anders Tengholm; Erik Gylfe; Hindrik Mulder; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ATP; Ca2 ; β-cell; α-cell; SERCA; SOCE; muscarinic receptor; insulin secretion; glucagon secretion; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Glucose metabolism in pancreatic α- and β-cells is believed to regulate secretion of glucagon and insulin, respectively. In β-cells, ATP links glucose metabolism to electrical activity and insulin secretion. LÄS MER

  5. 4. Regulation of proton-coupled electron transfer in cytochrome c oxidase : The role of membrane potential, proton pathways and ATP

    Författare :Markus Björck; Peter Brzezinski; Thorsten Friedrich; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cytochrome c oxidase; charge transfer; membrane potential; membrane protein; mitochondria; ATP; proton pump; Biochemistry; biokemi;

    Sammanfattning : Cytochrome c oxidase (CytcO) is the final electron acceptor of the respiratory chain. In this chain a current of electrons, derived from degradation of nutrients, along with protons, are used to reduce oxygen to water. The reaction is exergonic and the excess energy is used to pump protons across the membrane. LÄS MER

  7. 5. Characterization of ATP-dependent protein dynamics under native-like conditions

    Författare :Harsha Ravishankar; Magnus Andersson; Hans Wolf-Watz; Lise Arleth; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; proteins; membrane proteins; structural dynamics; ATPases; MD simulations; X-ray scattering; FTIR spectroscopy; ATP; TR-XSS; structural biology.; Biochemistry; biokemi;

    Sammanfattning : Proteins are biological macromolecules capable of accelerating biochemical reactions. To accomplish this, proteins undergo changes in their molecular structure. Advances in structural biology have resulted in ever-increasing numbers of high-resolution protein structures. LÄS MER