Sökning: "AT2 receptor"

Visar resultat 11 - 15 av 17 avhandlingar innehållade orden AT2 receptor.

  1. 11. Design and synthesis of -turn peptidomimetics : Applications to angiotensin II

    Författare :Susanna Lindman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; peptide synthesis; turn mimetics; molecular modelling; receptor binding affinity; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Organic Pharmaceutical Chemistry; organisk farmaceutisk kemi;

    Sammanfattning : This study addresses the issue of how to convert peptides into drug-like non-peptides while retaining the biological activity at peptide receptors. Angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, Ang II) was used as a model peptide. Small bioactive peptides are in most cases conformationally flexible molecules. LÄS MER

  3. 12. Design and Synthesis of 11C-Labelled Compound Libraries for the Molecular Imaging of EGFr, VEGFr-2, AT1 and AT2 Receptors : Transition-Metal Mediated Carbonylations Using [11C]Carbon Monoxide

    Författare :Ola Åberg; Bengt Långström; Nicholas Long; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; [11C]carbon monoxide; isotopic labelling; PET; acrylamide; EGFR; VEGFR-2; 11C; Organic chemistry; Organisk kemi; Organic Chemistry; Organisk kemi; Organic Pharmaceutical Chemistry; Organisk farmaceutisk kemi;

    Sammanfattning : This work deals with radiochemistry and new approaches to develop novel PET tracers labelled with the radionuclide 11C.Two methods for the synthesis of 11C-labelled acrylamides have been explored. LÄS MER

  4. 13. Angiotensin II Receptors in the Human Coronary Circulation and in Heart Failure

    Författare :Emil Pantev; Kardiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; Heart Failure; Human Coronary Arteries; Angiotensin II; AT receptors;

    Sammanfattning : Angiotensin II (Ang II) is a potent vasoconstrictor that is implicated in the pathogenesis of hypertension, heart failure and atherosclerosis. In this thesis, the efficacy and safety of Ang II receptor blockers (ARB) were evaluated. LÄS MER

  5. 14. Endothelin and angiotensin II receptors in human coronary arteries and bypass grafts - Alterations in cardiovascular disease

    Författare :Angelica Wackenfors; Lunds universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; vasoconstriction; receptors; cardiovascular disease; human; coronary arteries;

    Sammanfattning : Angiotensin II (Ang II) and endothelin-1 (ET-1) induce strong vasoconstriction via activation of receptors on vascular smooth muscle cells. In this thesis, the contractile Ang II and endothelin receptors were examined in endothelium-denuded human coronary arteries and in bypass grafts (the left internal mammary artery and the saphenous vein), with focus on receptor alterations in cardiovascular disease. LÄS MER

  7. 15. Mesentric hemodynamics and effects of angiotensin II during circulatory stress

    Författare :Mats Laesser; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Renin-angiontensin system; angiotensin II; intestines; hemodynamics; perfusion; hemorrhage; hypovolemia; endotoxemia;

    Sammanfattning : Mesenteric hypoperfusion and ischemia is considered to be deleterious to the intestinal mucosal barrier function and it is suggested that the renin-angiotensin system plays a pivotal role in the regulation of mesenteric perfusion.The present thesis examines the effects of the specific AT1 receptor blocker candesartan on mesenteric hemodynamics during acute hypovolemia and endotoxinemia. LÄS MER