Sökning: "AT2 receptor antagonist"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden AT2 receptor antagonist.

  1. 1. Design, Synthesis and Biological Evaluation of Selective Nonpeptide AT2 Receptor Agonists and Antagonists

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Charlotta Wallinder; Uppsala universitet.; [2008]
    Nyckelord :AT2 receptor agonist; AT2 receptor antagonist; Ang II peptidomimetics;

    Sammanfattning : The G protein-coupled receptors (GPCRs) are important targets in drug discovery. In several cases, the endogenous ligands that activate the GPCRs of pharmaceutical interest are peptides. LÄS MER

  2. 2. On angiotensin II receptor type 2 receptors in the small intestine

    Detta är en avhandling från Göteborg

    Författare :Sara Ewert; Göteborgs universitet.; Gothenburg University.; Göteborgs universitet.; Gothenburg University.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; renin-angiotensin; angiotensin; small intestine; mucosa; epithelium; AT1; AT2; bradykinin; BK2 receptor; nitric oxide; iNOS; smooth muscle; contractility;

    Sammanfattning : The endocrine renin-angiotensin system (RAS) is important in the regulation of extracellular fluid volume and systemic blood pressure in strenuous conditions such as hypovolemia. Also present locally in peripheral tissues, all components of RAS are expressed and have been shown to modulate development, cell growth and inflammation. LÄS MER

  3. 3. Computational prediction of ligand binding in peptide G-protein coupled receptors

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Silvana Vasile; Uppsala universitet.; [2019]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; GPCR; neuropeptide Y; angiotensin II receptor; molecular dynamics; free energy perturbation; homology modelling; computer simulations; peptide binding; peptidomimetics; binding free energy.;

    Sammanfattning : G-protein coupled receptors (GPCRs) are a superfamily of membrane receptors involved in a wide variety of biological processes, and their malfunction is associated with many diseases. Consequently, GPCRs are targeted by one-third of the drugs on the market, and constitute the focus of active public and private research in the search of more effective drugs. LÄS MER

  4. 4. Design and Synthesis of 11C-Labelled Compound Libraries for the Molecular Imaging of EGFr, VEGFr-2, AT1 and AT2 Receptors Transition-Metal Mediated Carbonylations Using [11C]Carbon Monoxide

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Ola Åberg; Uppsala universitet.; [2009]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; [11C]carbon monoxide; isotopic labelling; PET; acrylamide; EGFR; VEGFR-2; 11C; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi; Organisk kemi; Organic Chemistry; Organisk farmaceutisk kemi; Organic Pharmaceutical Chemistry;

    Sammanfattning : This work deals with radiochemistry and new approaches to develop novel PET tracers labelled with the radionuclide 11C.Two methods for the synthesis of 11C-labelled acrylamides have been explored. LÄS MER

  5. 5. Mesentric hemodynamics and effects of angiotensin II during circulatory stress

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Mats Laesser; Göteborgs universitet.; Gothenburg University.; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Renin-angiontensin system; angiotensin II; intestines; hemodynamics; perfusion; hemorrhage; hypovolemia; endotoxemia;

    Sammanfattning : Mesenteric hypoperfusion and ischemia is considered to be deleterious to the intestinal mucosal barrier function and it is suggested that the renin-angiotensin system plays a pivotal role in the regulation of mesenteric perfusion.The present thesis examines the effects of the specific AT1 receptor blocker candesartan on mesenteric hemodynamics during acute hypovolemia and endotoxinemia. LÄS MER