Sökning: "AT1"

Visar resultat 21 - 25 av 41 avhandlingar innehållade ordet AT1.

1. 21. Splanchnic organ homeostasis in experimental endotoxin shock : with special reference to the endothelin and renin-angiotensin systems

   Författare :Anders Oldner; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Endotoxin; endothelin; angiotensin II shock; tonometry microdialysis; porcine; hypoxanthine; gut; splanchnic circulation; lactate; mucosal pHi;

   Sammanfattning : Splanchnic organ homeostasis may become severely deteriorated in states of sepsis and endotoxaemia. Gut tissue hypoxia with subsequent increases in intestinal mucosal permeability has been proposed to contribute to the development of multiple organ failure. LÄS MER

3. 22. Design, Synthesis and Biological Evaluation of Selective Nonpeptide AT2 Receptor Agonists and Antagonists

   Författare :Charlotta Wallinder; Anders Hallberg; Mathias Alterman; Anders Karlén; Elizabeth E. Sugg; Uppsala universitet; []
   Nyckelord :AT2 receptor agonist; AT2 receptor antagonist; Ang II peptidomimetics;

   Sammanfattning : The G protein-coupled receptors (GPCRs) are important targets in drug discovery. In several cases, the endogenous ligands that activate the GPCRs of pharmaceutical interest are peptides. LÄS MER

4. 23. Protein Kinase Inhibition in Late Cerebral Ischemia after Subarachnoid Hemorrhage

   Författare :Saema Ansar; Lund Medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; neuropsychology; neurophysiology; Neurologi; protein kinase; cerebral ischemia; subarachnoid hemorrage; neurofysiologi; neuropsykologi;

   Sammanfattning : The cerebral ischemia that occur after a subarachnoid hemorrhage (SAH) often results in death or severe disability and is a significant cause of stroke. Our hypothesis is that cerebral ischemia leads to pathophysiological receptor changes on the vascular smooth muscle cells. LÄS MER

5. 24. Vascular mechanisms in ovulation

   Författare :Kenrokuro Mitsube; Göteborgs universitet; []
   Nyckelord :angiotensin; blood flow; nitric oxide; ovary; ovulation; permeability; permselectivity; rat.;

   Sammanfattning : Ovulation is a unique biological process, which involves the degradation and rupture of healthy tissue of the ovarian follicle and the extrusion of the oocyte. This process is initiated by the preovulatory surge of luteinizing hormone (LH), which leads to the up-regulation of various intraovarian mediators. LÄS MER

7. 25. Myocardial Effects of Type 2 Diabetes, Co-morbidities, and Changing Loading Conditions : a Clinical Study by Tissue Velocity Echocardiography

   Författare :Satish C. Govind; Lars-Åke Brodin; Mohbubul Alam; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical technology; Medicinsk teknik;

   Sammanfattning : Ever since the validation of the tissue velocity echocardiography (TVE) technique more than a decade ago the modality has been used rather successfully in various clinical situations, at rest as well as during stress echocardiography. Hitherto, dobutamine stress echocardiography has been the hallmark of all forms of stress procedures, now with TVE, quantification of the longitudinal motions of the left ventricle shows far superiority, with improved sensitivity and specificity in the functional diagnosis of coronary artery disease. LÄS MER