Sökning: "ASSAY"

Visar resultat 16 - 20 av 1591 avhandlingar innehållade ordet ASSAY.

  1. 16. Development of sensitive cellular assay systems and their application to the identification of "orphan" seven-transmembrane receptors

    Författare :Knut Kotarsky; Slemhinnans immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biokemi; Metabolism; Biochemistry; metabolism; leukotrieneB4; thiazolidinedione; 9-HODE; fatty acid; luciferase; GFP; reporter gene; preclinical assay; receptor; GPCR;

    Sammanfattning : Seven-transmembrane, G-protein coupled receptors play a central role in physiology since they facilitate cell communication in multicellular organisms by recognition of a broad range of ligands. They also represent important drug targets. LÄS MER

  3. 17. Testosterone and 17beta-oestradiol secretions in children and adolescents. Assay development, levels for comparison and clinical applications

    Författare :Carina Ankarberg-Lindgren; Göteborgs universitet; []
    Nyckelord :17beta-oestradiol; testosterone; sensitive assay; data for comparison; prepuberty; puberty; children; pubertal induction.;

    Sammanfattning : Accurate measurements of 17beta-oestradiol and testosterone are important in clinical settings of pubertal disorders and hormone replacement therapy among children. Most assays for measurement of these steroids are optimised for fertility investigations in adults and are not sensitive enough for quantification in children. LÄS MER

  4. 18. Circumventing drug resistance : Studies exploring the expediency of a total cell kill chemoresistance assay

    Författare :Bertil Jonsson; Uppsala universitet; []
    Nyckelord :Medical sciences; drug resistance; drug resistance assay; clinical correlations; cancer; human; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : Cellular resistance to anti-cancer drugs is considered to be the major cause of treatment failure in clinical practice. The present studies have therefore focused on ways to circumvent resistance as evaluated by an in vitro chemoresistance assay. LÄS MER

  5. 19. Application of Padlock Probe Based Nucleic Acid Analysis In Situ

    Författare :Sara Henriksson; Mats Nilsson; Ulf Landegren; Harvest Gu; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Padlock probe; rolling circle amplification; single cell gel electrophoresis assay; comet assay; Crimean Congo hemorrhagic fever virus; Molecular medicine; Molekylär medicin; Molekylär medicin; Molecular Medicine;

    Sammanfattning : The great variation displayed by nucleic acid molecules in human cells, and the continuous discovery of their impact on life, consequently require continuous refinements of molecular analysis techniques. Padlock probes and rolling circle amplification offer single nucleotide discrimination in situ, a high signal-to-noise ratio and localized detection within cells and tissues. LÄS MER

  7. 20. Health of municipal sewage workers : Studies of cancer incidence, biomarkers of carcinogenicity and genotoxicity, and self reported symptoms

    Författare :Lennart Friis; Uppsala universitet; []
    Nyckelord :Medical sciences; Abdominal symptoms; alkaline single cell gel assay; asthma; cancer; comet assay; dyspepsia; genotoxic exposure; Helicobacter pylori; IBS; occupational epidemiology; respiratory symptoms; sewage workers; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; arbets- och miljömedicin; Occupational and Environmental Medicine;

    Sammanfattning : The occupational exposures of sewage workers are complex and variable, and include a great variety of biological and chemical agents. Previous research has focused mostly on infections and various symptoms among sewage workers, e.g. abdominal and respiratory symptoms. LÄS MER