Sökning: "APP knockout"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden APP knockout.

  1. 1. On the Nature of β-Amyloid at Synapses

    Författare :Isak Martinsson; Experimentell demensforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; synapses; APP knockout; beta-Amyloid;

    Sammanfattning : Alzheimer’s disease is an aging related disorder of the mind, accountable for 60-80 percent of all cases of dementia. With its insidious progression and the decline of cognitive abilities, this disease is a major challenge for our society as a whole. LÄS MER

  3. 2. Interactive mechanism between beta-amyloid process, alfa7 nicotinic receptor, glial cell activation and oxidative stress in Alzheimer's disease

    Författare :Wen-Feng Yu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Abeta; Alzheimer s disease; astrocytes; brain development; nAChRs; neuritic plaques oxidative stress; transgenic mice; knockout mice;

    Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia with pathological features including the accumulation of neuritic plaques (NPs) and neurofibrillary tangles (NFTs). These degenerative processes are also accompanied by impaired cholinergic transmission, oxidative stress, activated glia and inflammation reaction. LÄS MER

  4. 3. Physiological roles of amyloid precursor protein in vivo - zebrafish as a model

    Författare :Jasmine Chebli; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloid-beta precursor protein; amyloid precursor protein-b; zebrafish; physiological functions; development; trigeminal ganglia; ependyma; cilia; proteomics; translational adaptation;

    Sammanfattning : Amyloid-beta precursor protein (APP) is an evolutionarily conserved transmembrane protein expressed in many different tissues. APP belongs to a gene family consisting of two other APP-like proteins (APLP1 and APLP2). LÄS MER

  5. 4. Interplay between autophagy and amyloid beta metabolism in Alzheimer’s disease

    Författare :Richeng Jiang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer’s disease (AD), the most common neurodegenerative disease, is characterized by two pathological hallmarks: extracellular amyloid-beta peptide (Aβ) plaque depositions and neurofibrillary tangles (NFTs) composed of intracellular hyperphosphorylated tau aggregations. A cellular degradation system, autophagy is additionally dysfunctional in AD and plays a key role in Aβ and tau metabolisms. LÄS MER

  7. 5. Effects of Alzheimer's and Parkinson's disease gene mutation on cell signaling

    Författare :Nodi Dehvari; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's disease (AD) and Parkinson's disease (PD) are the major neurodegenerative disorders affecting the elderly. The discovery of genes causing familial forms of these disorders has contributed enormously towards our understanding of underlying pathogenic mechanisms. LÄS MER