Sökning: "APOE"

Visar resultat 11 - 15 av 165 avhandlingar innehållade ordet APOE.

1. 11. Genes predisposing to type 2 diabetes and cardiovascular mortality

   Författare :Jenny Fredriksson; diabetes och endokrinologi Genomik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APOE; APM1; PPARG; PPARGC1A; survival abalysis; Medicin människa och djur ; Medicine human and vertebrates ; Type 2 Diabetes; cardiovascular mortality; glycogen synthase; adiponectin; GYS1;

   Sammanfattning : Cardiovascular complications are frequent in type 2 diabetes (T2D) and cardiovascular death is the most common cause of death for these individuals. A region on chromosome 19 (19q13) has been indicated by several genome scans as a susceptibility locus for T2D or components of the metabolic syndrome (MetS). LÄS MER

3. 12. Genes, lifestyle and coronary heart disease risk-epidemiological interaction studies

   Författare :Jaana Gustavsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Coronary heart disease; gene-lifestyle interaction; APOE; FTO; GHRL; smoking; physical activity; diet; obesity;

   Sammanfattning : Coronary heart disease (CHD) has multifactorial background involving both genetic and lifestyle factors, but much is still unknown about their interactions. The aim of this thesis was to study interactions focusing on apolipoprotein E (APOE), fat mass and obesity-related (FTO) and ghrelin/obestatin prepropeptide (GHRL) genes, as well as smoking, physical activity and diet. LÄS MER

4. 13. Proteomic Analysis of Urinary Bladder Cancer : Aiming for Novel Biomarkers

   Författare :Mårten Lindén; Per-Uno Malmström; Ulrika Segersten; Sara Bergström Lind; Lars Egevad; Uppsala universitet; []
   Nyckelord :urine; APOE; FGB; GAL1; LRG1; POLR1E; SERPINA1; STMN1; TOP2A; biomarker; diagnostic biomarker; prognostic biomarker; predictive biomarker; mass spectrometry; western blot; dot blot; immunohistochemistry; IHC; tissue microarray; TMA; urothelium; antibody; antibody-based; urinblåsecancer; biomarkör; diagnos; prognos; urin; proteomik; masspektrometri; immunohistokemi; antikroppar; Molecular Biology; Molekylärbiologi; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Urinary bladder cancer is a heterogeneous disease appearing in different forms, e.g. non-muscle invasive and muscle invasive. For all variants, the expression of proteins is interesting to analyze for diagnostic, predictive, prognostic and drug targeting purposes, since it reflects the altered gene expression causing the cancer. LÄS MER

5. 14. Telomeres and the brain : an investigation into the relationships of leukocyte telomere length with functional and structural attributes of the brain

   Författare :Mikael Wikgren; Karl-Fredrik Norrback; Rolf Adolfsson; Göran Roos; Thomas Karlsson; Brenda Penninx; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APOE; aging; atrophy; brain; cognition; cortisol; depression; hippocampus; HPA axis; MRI; stress; telomere length; white matter hyper-intensities.;

   Sammanfattning : Telomeres are the outermost parts of linear chromosomes. They consist of tandemly repeated non-coding short nucleotide sequences (TTAGGG in all vertebrates), in humans spanning over the last 2 to 15 kilobase pairs of the chromosome. Due to the end-replication problem, telomeres shorten with each cellular division. LÄS MER

7. 15. Novel host defence mechanisms during bacterial infections

   Författare :Malin Elvén; Lund Dermatologi och venereologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ApoE; Complement System; TFPI-2; Antimicrobial peptides; AMP; Immunolgobulins; endotoxins; Staphylococcus aureus; Pseudomonas aeruginosa; Escheria coli;

   Sammanfattning : The immune system has evolved through thousands of years and its architecture has challenged the medical field since the first hieroglyphs and will likely continue do so. With our co-evolution with millions of other species, the complexity to treat infectious diseases has been a race in increasing speed ever since. LÄS MER