Sökning: "APC resistance"

Visar resultat 16 - 20 av 20 avhandlingar innehållade orden APC resistance.

  1. 16. Restoring antitumor immunity with dendritic cell reprogramming strategies. Reprogramming cancer cells to antigen-presenting cells

    Författare :Alexandra Gabriela Barros Ferreira; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell Reprogramming; Cancer cells; Tumor Antigen-presenting Cells; immunotherapy;

    Sammanfattning : For the past two decades, immunotherapy revolutionized cancer treatment. However, responses vary significantly among eligible patients and some cancer types are not yet open to immunotherapy. Several mechanisms contribute to immunotherapy resistance, including loss of antigen presentation machinery and immunosuppression. LÄS MER

  3. 17. Clinical aspects on treatment of deep venous thrombosis with a low molecular weight heparin

    Författare :Margareta Holmström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Dalteparin is a low molecular weight heparin (LMWH) with a mean mw of 4-6000 D. Compared to unfractionated heparin (UFH), a higher bioavailability, a longer half-life and a more predictable dose-response is achieved after subcutaneous injections. LÄS MER

  4. 18. Novel immunization strategies and interethnic differences in response to malaria infection

    Författare :Charles Arama; Marita Troye-Blomberg; Kai Matuschewski; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Malaria; Immunization; Ethnic groups; vaccines; immunologi; Immunology;

    Sammanfattning : A better understanding of the role of antigen-presenting cells (APCs) in host resistance to malaria is essential to unravel the complex interactions between the host and the parasite. This would improve the design of malaria vaccines. LÄS MER

  5. 19. Studies of cytotoxic T lymphocytes and natural killer cells in relation to MHC class I presented peptides

    Författare :Lars Franksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :T-cell; NK cell; MHC class I; peptide;

    Sammanfattning : In the defense against disease it is essential for the immune system to be able to discriminate self/normal from non-self/abnormal. This key feature of the immune system relies on the presentation of antigens by MHC class I and class II molecules. LÄS MER

  7. 20. Recognition by and escape from CD8+ T cell immune surveillance in cancer bearing hosts

    Författare :Koji Kono; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : CD8+ T cells ( TCD8+ ) can specifically recognize tumor cells through MHC class I molecules associated with peptides that are 8-l0 amino acid residues long. In recent years, a number of tumor-associated antigens, or their epitopes, have been identified and characterized with the advent of new methods in molecular biology and in peptide isolation. LÄS MER