Sökning: "APC resistance"

Visar resultat 11 - 15 av 20 avhandlingar innehållade orden APC resistance.

  1. 11. Treatment of deep vein thrombosis and risk of recurrent venous thromboembolism

    Författare :Per Lindmarker; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Deep vein thrombosis; pulmonary embolism; low molecular mass heparin; therapy; outpatients; recurrent; risk factors; APC-resistance; factor V G1691A; prothrombin G20210A; side;

    Sammanfattning : A cute deep vein thrombosis (DVT) and pulmonary embolism (PE) are different clinical presentations of the same underlying disease, namely venous thromboembolism (VTE), which is a common and potentially fatal condition. Risk factors associated with the first and probably also subsequent events of VTE are hereditary or acquired. LÄS MER

  3. 12. Hypercoagulation in preeclampsia : implications for maternal health and fetal growth

    Författare :Shu He; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Preeclampsia (PE) is a serious complication of pregnancy characterized by hypertension, proteinuria, oedema and hypercoagulation. Damage in organs, such as the liver and kidney, is harmful to the maternal health. Impairments in placental function cause intrauterine growth retardation (IUGR). LÄS MER

  4. 13. Venous thromboembolism in women : risk factors and long term follow-up

    Författare :Kristina Sonnevi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Venous thromboembolism (VTE) is a common and potentially life threatening disease. Women have different risk factors than men at both first and recurrent VTE. The aim of this thesis was to further identify and explore risk factors for VTE in young and middle aged women. LÄS MER

  5. 14. Thrombin activatable fibrinolysis inhibitor (TAFI) in different hemorrhagic and thrombotic conditions

    Författare :Jovan P Antovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Thrombin activatable fibrinolysis inhibitor TAFI ; coagulation; fibrinolysis; thrombin; plasmin; factor V Leiden; hemophilia; von Willebrand disease; diabetes mellitus; preeclampsia;

    Sammanfattning : Until recently the coagulation and fibrinolytic systems were usually considered as separate entities. Accounts of a fibrinolysis inhibitor that is generated by thrombin shed more light on this field and changed the concept by giving thrombin, the pivotal enzyme in hemostasis, another important role in the down-regulation of fibrinolysis. LÄS MER

  7. 15. Dendritic cells in immune and gene therapy against cancer

    Författare :Andreas Lundqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dendritic cells; immunotherapy; gene therapy;

    Sammanfattning : Dendritic cells (DC) are extensively used for vaccine therapy due to their superior T cell stimulatory capacity. However, the modest therapeutic effects reported by most clinical trials using DC, together with the rapid developing field of DC biology suggests important considerations for improvement of the clinical outcome. LÄS MER