Sökning: "APC resistance"

Visar resultat 1 - 5 av 18 avhandlingar innehållade orden APC resistance.

  1. 1. Resistance to activated protein C a novel risk factor for venous thrombosis

    Författare :Peter Svensson; Malmö Klinisk koagulationsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APC resistance; mutation; venous thrombosis; blood coagulation; Protein C; factor V; Haematology; extracellular fluids; Hematologi; extracellulära vätskor;

    Sammanfattning : Activated protein C resistance (APC resistance) is the most common hereditary condition associated with venous thrombosis. The syndrome known as APC resistance is perfectly linked to a mutation in the gene coding coagulation FV (FV:Q506) mutation changing Arg 506 to Gln in the APC cleavage site. LÄS MER

  2. 2. Pro- and anticoagulant mechanisms in coronary artery disease. Clinical studies on factor VII and resistance to activated protein C

    Författare :Johan Holm; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein C; Factor VII; blood coagulation; myocardial infarction; APC resistance; Cardiovascular system; Kardiovaskulära systemet; warfarin;

    Sammanfattning : The triggering mechanism in myocardial infarction (MI) and unstable angina involves coronary thrombus formation following plaque rupture. Coagulation is initiated by tissue factor that activates factor VII (FVII), and is inhibited by protein C and its co-factor protein S. LÄS MER

  3. 3. Risk Estimation and Prediction of Preeclampsia, IUGR, and Thrombosis in Pregnancy

    Författare :Pelle Lindqvist; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gynaecology; andrology; Obstetrics; Thrombosis; Smoking; Risk estimation; Risk; Pregnancy; Preeclampsia; IUGR; Evolution; Fetal loss; Abortion; APC resistance; reproduction; Obstetrik; sexuality; sexualitet; reproduktion; andrologi; gynekologi;

    Sammanfattning : The aim of this thesis was to improve background knowledge for making a reliable medical evaluation at the first visit of a woman in her 13th gestational week, to the antenatal clinic. We have focused on the prediction and the risk estimation of preeclampsia, intra-uterine growth restriction (IUGR), and thrombosis. LÄS MER

  4. 4. Arterial Thrombosis in Factor V Leiden or Activated Protein C Resistance. Clinical and Experimental Studies

    Författare :Ellis Sampram; Malmö Klinisk koagulationsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Activated protein c resistance; Factor V Leiden mutation; thrombophilia; hypercoagulable state; Factor V Leiden mice; arterial thrombosis; venous thromboembolism; peripheral vascular reconstructions; peripheral vascular reconstruction occlusion;

    Sammanfattning : Abstract The last two decades has seen an avalanche of studies establishing Activated protein C (APC) resistance due to Factor V Leiden mutation as the most prevalent genetic risk factor, yet known, for venous thromboembolism. This has been documented in 20-60% of patients with deep vein thrombosis (DVT). LÄS MER

  5. 5. Structural and functional studies of factor V in health and disease

    Författare :Mårten Steen; Malmö Klinisk kemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; APC resistance and hemophilia; thrombosis; factor VIII; coagulation; factor V;

    Sammanfattning : The homologous blood coagulation factors V (FV) and factor VIII (FVIII) are important at sites of vascular injury for the amplification of the clotting cascade. Activated FV (FVa) serves as a cofactor to the enzyme activated factor X (FXa) in the activation of prothrombin. This complex is called the prothrombinase complex. LÄS MER