Sökning: "AMPK"
Visar resultat 11 - 15 av 58 avhandlingar innehållade ordet AMPK.
11. Regulation of carbohydrate metabolism in skeletal muscle during and after contraction
Sammanfattning : It is well known that exercise increases glucose transport into skeletal muscles. The regulation of this transport, however, is poorly understood. LÄS MER
12. AMP-activated protein kinase : the connection between exercise and type II diabetes
Sammanfattning : Skeletal muscle insulin resistance is a hallmark feature of Type 2 diabetes. Physical exercise/muscle contraction elicits an insulin-independent increase in glucose transport and perturbation of this pathway can bypass defective insulin signaling. LÄS MER
13. Metabolic and mitogenic transduction cascades in skeletal muscle : implications for exercise effects on glucose metabolism and gene regulation
Sammanfattning : Level of physical activity is linked to improved glucose homeostasis. The molecular signaling mechanisms by which insulin and exercise/muscle contractions lead to increased glucose transport and metabolism and gene expression have not been completely elucidated. LÄS MER
14. Gene expression in human skeletal muscle : effects of activity, fibre type and inheritance for diabetes
Sammanfattning : One fundamental underlying risk factor for the development of non-insulin dependent (type 2) diabetes mellitus is insulin resistance, which 80-90% of all type 2 diabetic patients suffer from. Risk factors for insulin resistance are for example obesity, surgery, severe illness, spinal cord injury, and pregnancy. LÄS MER
15. Kinase cascades in the regulation of glucose homeostasis
Sammanfattning : Therapeutic strategies to treat Type 2 Diabetes Mellitus (T2DM) aim at improving muscle insulin sensitivity by either directly modulating, or bypassing defective insulin signaling. Insulin induces metabolic and gene regulatory responses via PI 3-Kinase (PI3K) and Mitogen-Activated Protein Kinase (MAPK) signaling pathways, respectively. LÄS MER