Sökning: "AMP-activated protein kinase"

Visar resultat 16 - 20 av 23 avhandlingar innehållade orden AMP-activated protein kinase.

  1. 16. Studies on exercise and glycogen re-synthesis in skeletal muscles of pigs with the PRKAG3 mutation

    Författare :Anna Granlund; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : AMP-activated protein kinase (AMPK) plays an important role in the regulation of glucose and lipid metabolism in skeletal muscle. Many pigs of Hampshire origin have a naturally occurring mutation situated in the PRKAG3 gene which encodes a muscle-specific isoform of the AMPK γ3-subunit. LÄS MER

  3. 17. Adapt, Survive or Die - Metabolic Imbalances and the Enteric Nervous System

    Författare :Ulrikke Voss; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enteric nervous system; high fat diet; neuropathy; neuroplasticity; metabolic imbalance;

    Sammanfattning : Abstract: In this thesis the questions “do enteric neurons adapt to survive in conditions of obesity/type 2-diabetes (T2D) related metabolic imbalances? Or do they die?” are asked. Obese and T2D patients have high rates of gastrointestinal (GI) symptoms. LÄS MER

  4. 18. Novel pharmaceutical approaches to regulate glucose homeostasis

    Författare :Maj Sundbom; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Western sedentary life-style and calorie excess is causing an increased incidence of obesity and type 2 diabetes. When untreated, these diseases are associated with heart- and vascular disease, stroke, cancer, neuropathic pain, renal failure and infertility. LÄS MER

  5. 19. Regulation of whole-body glucose and lipid metabolism by skeletal muscle

    Författare :Milena Schönke; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Obesity and associated diseases like type 2 diabetes are rapidly growing health concerns across the globe. The uptake and expenditure of energy in the body are tightly regulated by a plethora of enzymes and hormones in central and peripheral tissues. LÄS MER

  7. 20. Mechanisms underlying mitochondrial function and biogenesis : implications for type 2 diabetes mellitus and obesity

    Författare :Maria H Holmström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :mitochondria;

    Sammanfattning : The ample supply of food, in conjunction with a sedentary lifestyle and certain genetic risk factors contribute to the rise in obesity, insulin resistance and type 2 diabetes mellitus. Reduced mitochondrial capacity for oxidative metabolism has been implicated as one possible cause of insulin resistance in several tissues; such as liver and skeletal muscle. LÄS MER