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Visar resultat 1 - 5 av 23 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. AMP-activated protein kinase in adipose tissue

    Författare :Franziska Kopietz; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AMPK; adipose tissue; adipocytes; diabetes; insulin; glucose uptake; lipolysis; FA synthesis; ADaM site activators;

    Sammanfattning : The AMP-activated protein kinase (AMPK) is a ubiquitously expressed kinase, which is activated in response to depletion of cellularenergy levels. Once active, it functions to alter cellular metabolism in a way that leads to restoration of energy levels. Therefore,AMPK is described as the key regulator of cellular energy homeostasis. LÄS MER

  3. 2. AMP-activated protein kinase : the connection between exercise and type II diabetes

    Författare :Brian R Barnes; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Skeletal muscle; glucose transport; AMP-activated protein kinase; AMPK gamma 3 exercise; Type 2 diabetes; insulin resistance; metabolism;

    Sammanfattning : Skeletal muscle insulin resistance is a hallmark feature of Type 2 diabetes. Physical exercise/muscle contraction elicits an insulin-independent increase in glucose transport and perturbation of this pathway can bypass defective insulin signaling. LÄS MER

  4. 3. Skeletal muscle metabolic flexibility : the roles of AMP-activated protein kinase and calcineurin

    Författare :Yun Chau Long; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Skeletal muscle; metabolism; glucose; lipid; gene expression; AMP-activated protein kinase; calcineurin; exercise;

    Sammanfattning : Skeletal muscle fibers differ considerably in their metabolic and physiological properties. The metabolic properties of skeletal muscle display a high degree of flexibility which adapts to various physiological demands by shifting energy substrate metabolism. LÄS MER

  5. 4. Global Regulation of Snf1 in Saccharomyces cerevisiae: A case study of experimental systems biology

    Författare :Jie Zhang; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; AMP-activated protein kinase AMPK ; glucose derepression; energy homeostasis; target of rapamycin complex 1 TORC1 ; catabolite repression; Snf1;

    Sammanfattning : Cells commonly face environmental changes and have evolved various regulatory mechanisms to adjust their metabolism accordingly. One such key regulator in S. cerevisiae is the Snf1 kinase, which belongs to the conserved AMP-activated protein kinase (AMPK) family in all eukaryotes. LÄS MER

  7. 5. LKB1 signaling pathways in adipocytes - Focus on the AMPK-related kinase SIK2

    Författare :Emma Henriksson; Proteinfosforylering; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipocytes; signal transduction; protein phosphorylation; LKB1; SIK2; SIK3; cAMP;

    Sammanfattning : Adipose tissue does not only store and release energy in response to hormones, it is also known as an endocrine organ, secreting important factors and hormones that influence for example appetite and insulin sensitivity. The association of type 2 diabetes with obesity has been known for quite some time. LÄS MER