Sökning: "AMP-activated protein kinase AMPK"

Visar resultat 6 - 10 av 20 avhandlingar innehållade orden AMP-activated protein kinase AMPK.

  1. 6. Dynamic control of the yeast AMPK/SNF1 pathway in response to glucose signals

    Författare :Loubna Bendrioua; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; AMPK; SNF1; Mig1; glucose signalling; dynamic control; mechanism; Saccharomyces cerevisiae;

    Sammanfattning : The SNF1/AMP-activated protein kinase (AMPK) belongs to a family of energy sensors that is conserved in all eukaryotes. Activated by ATP depletion, AMPK plays a vital role in restoring the energy balance by enhancing energy-generating and damping energy-requiring processes. LÄS MER

  3. 7. LKB1 signaling pathways in adipocytes - Focus on the AMPK-related kinase SIK2

    Författare :Emma Henriksson; Proteinfosforylering; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipocytes; signal transduction; protein phosphorylation; LKB1; SIK2; SIK3; cAMP;

    Sammanfattning : Adipose tissue does not only store and release energy in response to hormones, it is also known as an endocrine organ, secreting important factors and hormones that influence for example appetite and insulin sensitivity. The association of type 2 diabetes with obesity has been known for quite some time. LÄS MER

  4. 8. Molecular mechanisms governing contraction-induced metabolic responses and skeletal muscle reprogramming

    Författare :Stephan Glund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :AMP-activated protein kinase; interleukin-6; exercise; glucose metabolism; lipid metabolism; adaptation to exercise.;

    Sammanfattning : Physical exercise enhances skeletal muscle responsiveness to insulin and regulates metabolism by an insulin-independent mechanism. Elucidation of contraction-mediated molecular mechanisms is imperative for a better understanding of skeletal muscle metabolism and function, and may lead to the identification or validation of possible drug targets for the prevention or treatment of metabolic disorders. LÄS MER

  5. 9. Salt-inducible kinases in adipose tissue

    Författare :Johanna Sernevi Säll; Proteinfosforylering; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; salt-inducible kinase; SIK; SIK2; fettväv; fettceller; insulinsignalering; glukosupptag; fetma; insulinresistens; salt-inducible kinase; SIK; SIK2; adipose tissue; adipocytes; insulin signalling; glucose uptake; obesity; insulin resistance;

    Sammanfattning : Obesity, insulin resistance and type 2 diabetes (T2D) are metabolic diseases that increase rapidly in the modern society. The underlying mechanisms are complex and involve both environmental and genetic factors. Adipose tissue is an important organ for maintaining whole body energy homeostasis. LÄS MER

  7. 10. Peroxisome proliferator-activated receptor delta : regulation of skeletal muscle metabolism

    Författare :David Kitz Krämer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Peroxisome Proliferator-Activated Receptor PPAR 4 insulin sensitivity; insulin action; human skeletal muscle; primary cultured muscle cells; lipid-metabolism; glucose metabolism; AMP activated protein kinase AMPK ; Type 2 Diabetes Mellitus;

    Sammanfattning : Peroxisome Proliferator-Activated Receptor (PPAR) δ is a nuclear transcription factor which has been implicated in the regulation of lipid metabolism in skeletal muscle. In addition to the postural and locomotive functions of skeletal muscle, this organ has a major impact role on whole body metabolism. LÄS MER