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Visar resultat 1 - 5 av 9 avhandlingar som matchar ovanstående sökkriterier.
1. Growth factor signaling in the breast tumor microenvironment
Sammanfattning : Cancer represents a collection of malignancies characterized by an aberrant expansion of cells. This unrestrained growth is the result of the acquisition of several pro-survival features and the evasion of cellular fail-safe mechanisms, collectively known as the hallmarks of cancer. LÄS MER
2. Exploring the potential of antiangiogenic strategies targeting the TGF-β family in the tumor microenvironment
Sammanfattning : Members of the transforming growth factor (TGF)-β family exert their effect on virtually all cell types in the body, producing diverse and complex cellular responses. Additionally, TGF-β signaling is deregulated and hyperactive in many malignant conditions, making it an appealing target in the combat of cancer disease. LÄS MER
3. TGFβ Signal Transduction in Endothelial Cells
Sammanfattning : Transforming growth factor β (TGFβ) is a multifunctional cytokine that is involved in many biological effects, such as proliferation, migration, differentiation and cell survival. TGFβ regulates cellular responses by binding to a heteromeric complex of type I and type II serine/threonine kinase receptors. LÄS MER
4. TGF-β Family Signaling in Tumor Angiogenesis
Sammanfattning : Angiogenesis provides growing tumors a source of nutrients and oxygen, and a route for metastatic dissemination. In recent years anti-angiogenic therapies that primarily target the vascular endothelial growth factor (VEGF) signaling cascade have entered the clinic. LÄS MER
5. Small talk in the tumor microenvironment : the contribution of fibroblasts and endothelial cells to the malignant phenotype
Sammanfattning : Cancer is the result of aberrant cells developing into tumor cells that act in concert with the micro- and macroenvironment like any other organ in our bodies. The cells and molecules of the tumor microenvironment are important contributors to the tumorigenic process. LÄS MER