Sökning: "ALK1"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet ALK1.

  1. 1. Growth factor signaling in the breast tumor microenvironment

    Författare :Matteo Bocci; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; Tumor microenvironment; Angiogenesis; Cancer-associated fibroblasts; PDGF-C; ALK1;

    Sammanfattning : Cancer represents a collection of malignancies characterized by an aberrant expansion of cells. This unrestrained growth is the result of the acquisition of several pro-survival features and the evasion of cellular fail-safe mechanisms, collectively known as the hallmarks of cancer. LÄS MER

  3. 2. Exploring the potential of antiangiogenic strategies targeting the TGF-β family in the tumor microenvironment

    Författare :Sara Cunha; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Members of the transforming growth factor (TGF)-β family exert their effect on virtually all cell types in the body, producing diverse and complex cellular responses. Additionally, TGF-β signaling is deregulated and hyperactive in many malignant conditions, making it an appealing target in the combat of cancer disease. LÄS MER

  4. 3. TGFβ Signal Transduction in Endothelial Cells

    Författare :Gudrun Valdimarsdóttir; Peter ten Dijke; Carl-Henrik Heldin; Christer Betsholtz; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cellbiologi; Cell biology; Cellbiologi;

    Sammanfattning : Transforming growth factor β (TGFβ) is a multifunctional cytokine that is involved in many biological effects, such as proliferation, migration, differentiation and cell survival. TGFβ regulates cellular responses by binding to a heteromeric complex of type I and type II serine/threonine kinase receptors. LÄS MER

  5. 4. TGF-β Family Signaling in Tumor Angiogenesis

    Författare :Nikolas Eleftheriou; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Angiogenesis provides growing tumors a source of nutrients and oxygen, and a route for metastatic dissemination. In recent years anti-angiogenic therapies that primarily target the vascular endothelial growth factor (VEGF) signaling cascade have entered the clinic. LÄS MER

  7. 5. Small talk in the tumor microenvironment : the contribution of fibroblasts and endothelial cells to the malignant phenotype

    Författare :Charlotte Anderberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer is the result of aberrant cells developing into tumor cells that act in concert with the micro- and macroenvironment like any other organ in our bodies. The cells and molecules of the tumor microenvironment are important contributors to the tumorigenic process. LÄS MER