Sökning: "ADAMTS13"

Hittade 5 avhandlingar innehållade ordet ADAMTS13.

  1. 1. Studies of ADAMTS13 expression and activity in the kidney

    Författare :Ramesh Tati; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ADAMTS13; von WIllebrand factor; thrombotic thrombocytopenic purpura;

    Sammanfattning : Von Willebrand factor (VWF) is an abundant plasma glycoprotein involved in platelet adhesion and aggregation at sites of vascular injury. ADAMTS13 is the sole physiological VWF-cleaving protease, thus regulating the size of thrombus growth. LÄS MER

  3. 2. ADAMTS13 phenotype in health and disease with special reference to thrombotic thrombocytopenic purpura

    Författare :Minola Manea Hedström; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urology; tubular cells; podocytes; kidney; plasma; ADAMTS13; thrombotic thrombocytopenic purpura; nephrology; Urologi; nefrologi; Pediatrics; Pediatri;

    Sammanfattning : Von Willebrand factor (VWF) is synthesized and secreted by endothelial cells into the plasma as a series of multimers. VWF induces the formation of platelet plugs at sites of vascular injury and high shear stress. Biological activity is dependent on multimeric size, which is regulated in plasma by the VWF-cleaving protease ADAMTS13. LÄS MER

  4. 3. The hemostatic pathway in ischemic stroke. Clinical studies of genetic variation and plasma protein measurements

    Författare :Ellen Hanson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ischemic stroke; etiologic subtypes of ischemic stroke; genetics; SNP; hemostasis; prothrombotic; ADAMTS13; VWF; ABO blood group; FSAP; FXI;

    Sammanfattning : Although stroke is a common cause of death and disability in adults, there are few studies on stroke compared to other common diseases. A stroke could be either ischemic or hemorrhagic, but even within these two groups, disease etiology shows heterogeneity. LÄS MER

  5. 4. Studies of haemostasis in acute coronary syndromes and diabetes mellitus

    Författare :Mika Skeppholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The pathophysiology of acute coronary syndromes (ACS) includes atherosclerotic plaque rupture and coronary thrombus formation. Antithrombotic treatment is effective but recurrent atherothrombotic or bleeding complications are not uncommon. LÄS MER

  7. 5. Effects of in vitro fertilization on thrombosis and haemostasis and the relationship between infertility and cardiovascular disease

    Författare :Eli Westerlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Infertility afflicts more than 10% of all couples worldwide. In vitro fertilization (IVF) is now performed at an ever increasing rate. There is scarce information concerning the associations between cardiovascular disease (CVD), venous thromboembolism (VTE) and infertility. LÄS MER