Sökning: "ACAT2"

Hittade 3 avhandlingar innehållade ordet ACAT2.

1. 1. Regulation of the hepatic ACAT2 expression and roles of HNF1alhpa and HNF4alpha in cholesterol metabolism

   Författare :Camilla Pramfalk; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :ACAT2; HNF; MODY; NPC1L1; SREBP; cholesterol metabolism;

   Sammanfattning : Acyl-Coenzyme A:cholesterol acyltransferases (ACATs) 1 and 2 are integral membrane proteins located in rough endoplasmatic reticulum that catalyzes the formation of cholesteryl esters (CEs) from cholesterol and long-chain fatty acids. ACAT1 is present in most tissues, whereas ACAT2 is confined to enterocytes and hepatocytes. LÄS MER

3. 2. Studies on cholesterol and bile acid metabolism in Chinese cholesterol gallstone patients

   Författare :Zhao-Yan Jiang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cholesterol gallstone disease; ABCG5 ABCG5; SRBI; ACAT2; Gender; Bile acids; Liver; Intestine;

   Sammanfattning : Liver and intestine are important organs for the metabolism of cholesterol and bile acids in the body. Dysfunction in cholesterol and bile acid metabolism may lead to diseases such as cholesterol gallstone (GS) disease and atherosclerosis. LÄS MER

4. 3. Role of cholesterol metabolism in hepatic steatosis and glucose tolerance

   Författare :Osman Salih Osman Ahmed; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The liver is the central organ for lipid, lipoprotein and glucose homeostasis, thus hepatic metabolic disturbances can predispose individuals to develop cardiometabolic disorders (CMD) such as atherosclerotic cardiovascular diseases (ASCVD), type 2 diabetes mellitus (T2DM), and nonalcoholic fatty liver disease (NAFLD).The overall aim of this thesis was to expand the knowledge on how genetic and pharmacological interventions on hepatic and intestinal cholesterol metabolism could affect the pathophysiology of CMD. LÄS MER