Sökning: "ABCB11"

Hittade 3 avhandlingar innehållade ordet ABCB11.

  1. 1. ATP-Binding-Cassette Transporters in Biliary Efflux and Drug-Induced Liver Injury

    Författare :Jenny M. Pedersen; Per Artursson; Christel A. S. Bergström; Stefan Oswald; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ABC transport protein; Pgp; P-glycoprotein; ABCB1; BCRP; breast cancer resistance protein; ABCG2; MRP2; multidrug resistance-associated protein 2; ABCC2; BSEP; bile salt export pump; ABCB11; sandwich cultured human hepatocytes; SCHH; drug-induced liver injury; DILI; multivariate data analysis; OPLS; Galenisk farmaci; Pharmaceutics;

    Sammanfattning : Membrane transport proteins are known to influence the absorption, distribution, metabolism, excretion and toxicity (ADMET) of drugs. At the onset of this thesis work, only a few structure-activity models, in general describing P-glycoprotein (Pgp/ABCB1) interactions, were developed using small datasets with little structural diversity. LÄS MER

  3. 2. Progressive familial intrahepatic cholestasis : clinical, biochemical, genetic and histopathological aspects

    Författare :Henrik Arnell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Progressive familial intrahepatic cholestasis PFIC ; genetic linkage analysis; ABCB11; immunohistochemistry; partial external biliary diversion PEBD ; nuclear scintigraphy; fibrosis; histological regress;

    Sammanfattning : In the early 1980's, most cases of neonatal cholestasis (often referred to as neonatal hepatitis) remained unexplained. By today, many of these diseases have been characterized in detail. LÄS MER

  4. 3. Intrahepatic cholestasis of pregnancy

    Författare :Anna Glantz; Göteborgs universitet; []
    Nyckelord :Intrahepatic cholestasis of pregnancy ICP ; pruritus; fetal risk; ursodeoxycholic acid; dexamethasone; ABCB4-gene; haplotypes; sulphated progesterone metabolites;

    Sammanfattning : Intrahepatic cholestasis of pregnancy (ICP) is a condition that has been reported to be associated with an increased fetal risk. A prospective study of ICP was conducted in the Västra Götaland region of Sweden between February 1, 1999 and January 31, 2002. LÄS MER