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Visar resultat 1 - 5 av 87 avhandlingar som matchar ovanstående sökkriterier.
1. Abdominal aortic aneurysm inception and evolution - A computational model
Sammanfattning : Abdominal aortic aneurysm (AAA) is characterized by a bulge in the abdominal aorta. AAA development is mostly asymptomatic, but such a bulge may suddenly rupture, which is associated with a high mortality rate. Unfortunately, there is no medication that can prevent AAA from expanding or rupturing. LÄS MER
2. Abdominal Aortic Aneurysm : Molecular Imaging Studies of Pathophysiology
Sammanfattning : The pathological process behind abdominal aortic aneurysm (AAA) formation is poorly understood and difficult to study. The aim of the thesis was to study the pathophysiology of AAA formation with positron emission tomography (PET) technology, a molecular imaging technique, allowing in vivo studies of pathophysiological changes. LÄS MER
3. Vascular remodelling and circulating basement membrane fragments in abdominal aortic aneurysm
Sammanfattning : An abdominal aortic aneurysm (AAA) is a degenerative disease, characterized by advanced inflammation and extracellular matrix (ECM) remodelling. Enhanced protease activity mediated by cytokines results in the degradation of ECM proteins, leading to the generation of different bioactive fragments. LÄS MER
4. Actions of androgens and estrogens in experimental models of cardiovascular disease
Sammanfattning : Men are at higher risk of developing both atherosclerotic cardiovascular disease and abdominal aortic aneurysm (AAA). Actions of sex steroids are hypothesized to underlie these gender differences. Testosterone, the major androgen, reduces atherosclerosis in male animal models but is suggested to promote AAA formation. LÄS MER
5. Structure and mechanism of iron and magnesium chelatases - at the heme-chlorophyll branch-point
Sammanfattning : Tetrapyrroles are synthesised through a single branched biosynthetic pathway. Heme and chlorophyll are synthesised from the common intermediate protoporphyrin IX at the heme-chlorophyll branch-point. LÄS MER