Sökning: "A. Elisabeth Sauer-Eriksson"
Visar resultat 1 - 5 av 12 avhandlingar innehållade orden A. Elisabeth Sauer-Eriksson.
1. Transthyretin and the transthyretin-related protein: A structural study
Sammanfattning : Transthyretin (TTR) is one of several proteins involved in amyloid disease in humans. Unknown conformational changes of the native state of TTR result in aggregation of TTR molecules into amyloid fibrils, which accumulate in extracellular tissues. This may result in different clinical symptoms, e.g. LÄS MER
2. Disarming bacteria : a structure-based approach to design an anti-virulence drug against Listeria monocytogenes
Sammanfattning : Antibiotic resistances are one of the biggest threats to global health and if we don’t change our behavior and way of using antibiotics we will end up in a ‘post-antibiotic era’, in which common infections and minor injuries can once kill again and up to 10 million deaths per year may occur by 2050. Therefore, there is a high need for new anti-bacterial drugs, especially of alternatives to existing antibiotics with already described resistances. LÄS MER
3. Structural and functional properties of transthyretin
Sammanfattning : The hereditary transthyretin (TTR) amyloidoses are rare, and in severe cases, fatal disorders caused by mutations in the TTR gene. The clinical picture is diverse, involving neuropathies and myopathies, and mainly depends on the causative mutation and the sites and rates of amyloid deposition. LÄS MER
4. In silico Identification of Thyroid Disrupting Chemicals : among industrial chemicals and household dust contaminants
Sammanfattning : Thyroid disruptions by xenobiotics have been associated with a broad spectrum of severe adverse human health effects, such as impaired brain development and metabolic syndrome. Ingestion of indoor dust and contact with industrial chemicals are two significant human exposure routes of thyroid hormone disrupting chemicals (THDCs), raising serious concerns for human health. LÄS MER
5. Exploring the mechanistic details of Gram-positive Type 4 Secretion Systems
Sammanfattning : Hospital acquired (i.e. nosocomial) infections and antibiotic resistance are large issues in the world today, with about 1.3 million people estimated to have died from antibiotic resistant infections in 2019 alone, and these problems are on the rise. LÄS MER
