Sökning: "A receptors"

Visar resultat 1 - 5 av 2106 avhandlingar innehållade orden A receptors.

  1. 1. Signaling via Orexin Receptors A Pharmacological Study

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Tomas Holmqvist; Jyrki Kukkonen; Karl Åkerman; Gunnar Flemström; Per Svenningsson; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; orexin; receptors; calcium; cAMP; adenylyl cyclases; Fysiologi; MEDICINE Physiology and pharmacology Physiology; MEDICIN Fysiologi och farmakologi Fysiologi;

    Sammanfattning : The orexin receptors are a pair of newly discovered G-protein coupled receptors which are activated by the neuropeptides orexins and play a role in sleep/vigilance, apetite/metabolism and neuroendocrine regulation. On a cellular level receptor activation results in, to name but a few effects, elevation of intracellular calcium and depolarisation. LÄS MER

  2. 2. Hyaluronan receptors of liver endothelial cells, their purification and characterisation

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Peter A. G. McCourt; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; hyaluronan; scavenger receptors; ICAM-1; liver endothelial cells; Biokemi; MEDICINE Chemistry Biochemistry; MEDICIN Kemi Biokemi; fysiologi; Physiology;

    Sammanfattning : Hyaluronan (HA) is a polysaccharide common throughout the connective tissues. and is found at low concentrations in the blood. The major site of its clearance is via an endocytic receptor on liver endothelial cells (LEC). This process is vital, as excessive serum levels of HA lead to clotting disorders and overly viscous blood. LÄS MER

  3. 3. Hematopoiesis, Kazal Inhibitors and Crustins in a Crustacean

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Young-A Kim; Kenneth Soderhall; Irene Soderhall; Shun-ichiro Kawabata; [2006]
    Nyckelord :Biochemistry; innate immunity; cytokine; hematopoietic tissue; ATP synthase β subunit; Kazal; antibacterial peptides; Biokemi;

    Sammanfattning : Hemocytes are important as storage and producers of proteins of the innate immune defence, as well as actors of the cellular immune response. Therefore the hematopoietic process is critical for survival of most invertebrates. LÄS MER

  4. 4. Lymphangiogenesis and lymphatic metastasis

    Detta är en avhandling från Stockholm : Karolinska Institutet, Microbiology and Tumor Biology Center (MTC)

    Författare :Meit A Björndahl; Karolinska Institutet.; Karolinska Institutet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Angiogenesis; lymphangiogenesis; lymphatic metastasis; PDGF; IGF; VEGF-A;

    Sammanfattning : The major cause of cancer mortality is metastasis, which relies on the growth of blood vessels (haemangiogenesis) and lymphatic vessels (lymphangiogenesis). Whereas the field of haemangiogenesis has been relatively thoroughly studied, little is known about the mechanisms regulating lymphangiogenesis. LÄS MER

  5. 5. Computational Modelling of Ligand Complexes with G-Protein Coupled Receptors, Ion Channels and Enzymes

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Lars Boukharta; Johan Åqvist; Christopher A. Reynolds; [2014]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; computer simulations; molecular dynamics; ligand binding; free energy perturbation; linear interaction energy; binding free energy; homology modelling; structure prediction; alanine scanning; site-directed mutagenesis; hERG; GPCR; neuropeptide Y; HIV-1 reverse transcriptase; integron integrase; Molecular Biotechnology; Molekylär bioteknik;

    Sammanfattning : Accurate predictions of binding free energies from computer simulations are an invaluable resource for understanding biochemical processes and drug action. The primary aim of the work described in the thesis was to predict and understand ligand binding to several proteins of major pharmaceutical importance using computational methods. LÄS MER