Sökning: "A Gogoll"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden A Gogoll.

  1. 1. Towards the Development of Photoswitchable β-Hairpin Mimetics

    Författare :Máté Erdélyi; Adolf Gogoll; Anders Karlén; John A. Robinson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; β-hairpin; peptidomimetics; Sonogashira; NMR; photochemistry; microwave; peptide; palladium; Organisk kemi; Organic chemistry; Organisk kemi;

    Sammanfattning : Peptide secondary structure mimetics are important tools in medicinal chemistry, as they provide analogues of endogeneous peptides with new physicochemical and pharmacological properties. The β-hairpin motif has been shown to be involved in numerous physiological processes, among others in regulation of eucariotic gene transcription. LÄS MER

  3. 2. Discovery of Secondary Metabolites from Rwandese Medicinal Plants : Isolation, Characterization and Biological Activity

    Författare :Daniel Umereweneza; Máté Erdélyi; A Gogoll; Théoneste Muhizi; Yngve Stenstrøm; Uppsala universitet; []
    Nyckelord :Natural products; Nuclear Magnetic Resonance NMR ; Dihydrochalcones; Iridoids; Silphiperfolanols; Pyrrolizidine alkaloids PAs ; Rwandese Medicinal Plants; Chemistry with specialization in Organic Chemistry; Kemi med inriktning mot organisk kemi;

    Sammanfattning : Plants have served as the principal source of medicines in different parts of the world through the ages. Herb-derived medicines have been used as decoctions, infusions, tinctures or single substance drugs. LÄS MER

  4. 3. Synthesis of Molecular Probes for Exploring the Human Consciousness, 5-HT7 Ligands and Salvinorins

    Författare :Pär Holmberg; Anders Karlén; Adolf Gogoll; Anette Johansson; Christer Sahlberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; serotonin system; opioid system; selective 5-HT7 agonist; 3-aminchromans; salvinorin A; selective kappa opioid receptor; mental disorders; consciousness; regioselective oxidation; enzymatic kinetic resolution; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Sammanfattning : In this study, we have addressed the serotonergic and the opioid system within the CNS. Both systems are of outmost importance in the etiology of disease states, especially mental disorders. LÄS MER

  5. 4. Bispidine Derivatives : Synthesis and Interactions with Lewis Acids

    Författare :Lauri Toom; Adolf Gogoll; Helena Grennberg; Frode Rise; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; bispidines; NMR; basicity; structural information; palladium; complexes; Organisk kemi; Organic chemistry; Organisk kemi;

    Sammanfattning : In this thesis, the improved synthesis and investigations into the properties of some 3,7-diazabicyclo[3.3.1]nonane (bispidine) derivatives are described. LÄS MER

  7. 5. Photoswitchable Peptidomimetics : Synthesis and Photomodulation of Functional Peptides

    Författare :Miranda Varedian; Adolf Gogoll; Morten Grøtli; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; β-hairpin; peptidomimetics; stilbene; thioaurone; photochemistry; Organic chemistry; Organisk kemi;

    Sammanfattning : The secondary structure of peptides is of pivotal importance for their biological function. The introduction of photoswitchable moieties into the backbones of peptides provides a unique way of regulating their conformation using an external stimulus, i.e., light. LÄS MER