Sökning: "A Alt"

Visar resultat 21 - 25 av 70 avhandlingar innehållade orden A Alt.

  1. 21. Studies of drug safety in the treatment of rheumatoid arthritis

    Författare :Johanna Karlsson Sundbaum; Eva Baecklund; Mia Wadelius; Pär Hallberg; Peter Michaelson; Gerd-Marie Alenius; Uppsala universitet; []
    Nyckelord :Drug safety; Rheumatoid arthritis; Hepatotoxicity; Methotrexate; MTHFR; GWAS; tuberculosis; screening;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting mainly smaller joints. Patients are at risk for complications as joint destruction, but starting treatment soon after onset of disease, has reduced the risk for complications. LÄS MER

  3. 22. Alternating Coding and its Decoder Architectures for Unary-Prefixed Codes

    Författare :Shang Xue; Bengt Oelmann; Jukka Teuhola; Mittuniversitetet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Electronics; Elektronik;

    Sammanfattning : The entropy coding of high peak, heavy-tailed probability distributions such as the Laplacian, Cauchy, and generalized Gaussian have been a topic of interest because they are able to provide good models for data in many coding systems, especially in image and video coding systems. This thesis studies the entropy coding of such high peak, heavy-tailed probability distributions. LÄS MER

  4. 23. Understanding the genetic architecture of fatty liver disease

    Författare :Jamialahmadi Oveis; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Non-alcoholic fatty liver disease; Polygenic risk score; Genomewide association studies; Mendelian Randomization;

    Sammanfattning : Non-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease, ranging from simple steatosis to more severe conditions, namely non-alcoholic steatohepatitis (NASH), liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). NAFLD has a strong genetic component, and its heritability depends on environmental factors and ethnicity. LÄS MER

  5. 24. Peroxisome proliferator-activated receptor delta (PPARD) : molecular studies of regulation and activation

    Författare :Petra Thulin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors involved in energy homeostasis. Their natural ligands are fatty acids and there are three different PPAR isoforms; PPARA, PPARG and PPARD. LÄS MER

  7. 25. On evaluation of organ damage in perinatal asphyxia : an experimental and clinical study

    Författare :Mathias Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Perinatal asphyxia; hypoxia-ischemia; hypothermia; pig; lactate dehydrogenase; aminotransferases;

    Sammanfattning : Leakage of intracellular enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) signalling multi organ dysfunction (MOD) is seen together with hypoxic ischemic encephalopathy (HIE) after perinatal asphyxia. Hypothermia (HT) can attenuate HIE following perinatal asphyxia and hypoxia-ischemia (HI) but the neuroprotective efficacy falls dramatically the longer the delay in initiating HT. LÄS MER