Sökning: "9-hydroxyrisperidone"

Hittade 2 avhandlingar innehållade ordet 9-hydroxyrisperidone.

  1. 1. Pharmacogenetics and Antipsychotic Treatment in Schizophrenia with Special Focus on Adverse Drug Reactions

    Författare :Arzu Gunes; Marja-Liisa Dahl; Maria Gabriella Scordo; Kristina I. Melkersson; Jürgen Brockmöller; Uppsala universitet; []
    Nyckelord :Medicine; Pharmacogenetics; schizophrenia; antipsychotic treatment; adverse effects; clinical outcome; Medicin;

    Sammanfattning : Genetically determined differences in drug metabolism and disposition and drug targets play a pivotal role in the interindividual variability in the clinical outcome of antipsychotic treatment. The aim of this thesis was to study the impact of polymorphisms in genes involved in the pharmacokinetics and pharmacodynamics of antipsychotics, with special focus on their extrapyramidal and metabolic adverse effects. LÄS MER

  3. 2. Drug metabolic capacity in Koreans : CYP2D6 & CYP2C19 pheno- and genotype relationships in healthy volunteers and in patients

    Författare :Hyung-Keun Roh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Drug metabolism; phenotype; genotype; CYP2D6; CYP2C 19; Korean; haloperidol; risperidone; omeprazole; gastric pH; gastrin; schizophrenia; patient.;

    Sammanfattning : This thesis aimed to investigate the relationship between pheno- and genotype of two drugmetabolizing enzymes CYP2D6 and CYYP2C19 in Koreans. Population studies were conducted in healthy volunteers to obtain basic information on these two enzymes. LÄS MER