Sökning: "89Zr"
Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet 89Zr.
1. Radionuclide Production with PET Cyclotrons, Applications and Preclinical Experiments
Sammanfattning : Nuclear medicine is based on the radiotracer principle of George de Hevesy and the magic bullet concept by Ehrlich and focuses on the diagnosis, the treatment of diseases and the investigation of normal states within the human body using radiopharmaceuticals. A radiopharmaceutical is an atom or a chemical compound in which one or several atoms are replaced with a radionuclide. LÄS MER
2. Optimization of in vivo cell tracking methods with long-lived radionuclides for PET imaging
Sammanfattning : Stem cell transplantation and cell therapy are the standard treatments for many diseases; however, many suffer from complications, and the therapeutic efficiency can be challenging to predict. The off-target accumulation of the transplanted cells can cause some of these shortcomings. LÄS MER
3. Radiolabelled affibody molecules for imaging EGFR expression in tumours
Sammanfattning : Affibody molecules are promising scaffold-based targeting proteins for radionuclide imaging and cancer therapy. This thesis is based on 5 original research articles (Papers I-V), with the primary focus being placed on the optimization of molecular design of EGFR-binding affibody variants for high contrast imaging of epidermal growth factor receptor (EGFR) expression in tumours. LÄS MER
4. Development of radiometal-based labelling techniques and tracers for non-invasive molecular imaging
Sammanfattning : Metallic radionuclides, radiometals, have an important role in nuclear medicine. Their straightforward coordination radiochemistry allows for a large variety of applications. LÄS MER
5. Combinatorial Protein Engineering Of Affibody Molecules Using E. Coli Display And Rational Design Of Affibody-Based Tracers For Medical Imaging
Sammanfattning : Directed evolution is today an established strategy for generation of new affinity proteins. This thesis describes the development of a cell-display method using Escherichia coli for directed evolution of Affibody molecules. LÄS MER