Sökning: "6-hydroxydopamine"

Visar resultat 11 - 15 av 23 avhandlingar innehållade ordet 6-hydroxydopamine.

  1. 11. Non-motor symptoms in Parkinson’s disease : modeling and mechanisms

    Författare :Débora Masini; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Parkinson’s disease (PD) is a common neurodegenerative disorder, typically characterized by the progressive death of midbrain dopaminergic neurons projecting from the substantia nigra to other areas within the basal ganglia. Historically, PD has been diagnosed as a purely motor disorder dominated by bradykinesia (slowness of movement), rigidity, resting tremor, and postural instability. LÄS MER

  3. 12. Mechanisms of motor and non-motor complications in experimental parkinsonism

    Författare :Carina Plewnia; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Parkinson’s disease (PD), one of the most common neurodegenerative disorders, is classically characterized by the progressive loss of midbrain dopaminergic neurons and by the emergence of cardinal motor symptoms including rigidity, tremor and bradykinesia. PD treatment relies on pharmacological dopamine replacement, which is the most effective therapy to alleviate motor symptoms. LÄS MER

  4. 13. The circuit and synaptic organization of the basal ganglia output : mechanistic insights on movement disorders and action control

    Författare :Giacomo Sitzia; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Understanding the neural circuitry underlying movement is a neuroscientific challenge that promises to help refining currently available treatments for movement disorders. Key structures for movement and action control are the basal ganglia nuclei, whose complexity has only just started to be resolved. LÄS MER

  5. 14. Cell and Gene Therapy for Parkinson's Disease: Therapeutic Effect and Modulation of Dyskinesias in the 6-OHDA Rat Model

    Författare :Thomas Carlsson; Brain Repair and Imaging in Neural Systems (BRAINS); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; Pharmacological sciences; pharmacognosy; pharmacy; neurofysiologi; Medicin människa och djur ; Neurology; neuropsychology; neurophysiology; Neurologi; Medicine human and vertebrates ; Parkinson?s disease; Serotonin; Tyrosine hydroxylase; Ventral mesenchephalon; Motor behavior; L-DOPA; GTP cyclohydrolase 1; Gene therapy; Dyskinesias; Cell transplantation; Dopamine; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Sammanfattning : The main pathological feature in Parkinson's disease is the progressive loss of dopamine neurons in the midbrain, which in turn leads to the appearance of motor deficits such as akinesia/bradykinesia (loss/slowness of movements), rigidity, postural imbalance and tremor. To this day, there is no cure for the disease, but there are medications to relieve the symptoms. LÄS MER

  7. 15. Functional MRI characterization of animal models of parkinsonism

    Författare :Cyril Monnot; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Parkinson's disease (PD) is the second most common neurological disorder. It is characterized by the progressive development of motor symptoms - bradykinesia, resting tremor, muscular rigidity and difficulty with postural control - which serve as criterias for its clinical diagnosis. LÄS MER