Sökning: "5-Lipoxygenase activating protein"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden 5-Lipoxygenase activating protein.

1. 1. Studies on coactosin-like protein interaction with 5-lipoxygenase

   Författare :Marija Rakonjac; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Leukotrienes (LTs) are proinflammatory lipid mediators derived from polyunsaturated arachidonic acid, which is ester-bound at the sn-2 position of glycerol in cellular phospholipid bilayers. In LTs biosynthesis, 5-lipoxygenase (5-LO) represents the key enzyme, which catalyzes two initial steps. LÄS MER

3. 2. Structural and functional studies of microsomal glutathione transferase 1

   Författare :Peter J Holm; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Glutathione transferase; membrane protein; three-dimensional structure; elecron crystallography; hydrophobic binding stoichiometry; H D exchange mass spectrometry;

   Sammanfattning : The microsomal glutathione transferase 1 (MGST1) is present in high amounts in the endoplasmic reticulum (ER) as an integral homo-trimeric membrane protein with a molecular weight of 51.9 kDa. LÄS MER

4. 3. The enzymatic machinery of leukotriene biosynthesis : Studies on ontogenic expression, interactions and function

   Författare :Tobias Strid; Sven Hammarström; Mats Söderström; Ralf Morgenstern; Linköpings universitet; []
   Nyckelord :;

   Sammanfattning : Leukotrienes (LTs) are biologically active arachidonic acid (AA) derivatives generated by the 5-lipoxygenase (5-LO) pathway. They are produced by myeloid cells. 5-LO converts AA to LTA4 in cooperation with 5-LO activating protein (FLAP). LTA4 is converted to LTB4, by LTA4-hydrolase (LTA4H) or to LTC4 by LTC4-synthase (LTC4S). LÄS MER

5. 4. Role of inflammatory and mitochondria genes in adipose tissue and obesity

   Författare :Maria Kaaman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Obesity is rapidly increasing in prevalence around the world together with its complications such as dyslipidemia, cardiovascular disease (CVD) and insulin resistance, which eventually may lead to type 2 diabetes (T2DM). The excess of adipose tissue, the hallmark of obesity, led us to study the adipose tissue as a contributor to obesity and insulin resistance. LÄS MER

7. 5. Studies on leukotriene B4 and alarmins in inflammatory responses

   Författare :Min Wan; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Leukotriene B4 (LTB4) is a potent proinflammatory lipid mediator that is involved in host defense and inflammatory diseases, such as atherosclerosis. LL-37 and heparin binding protein (HBP) are cationic antimicrobial polypeptides, which belong to the alarmin family known to promote innate and adaptive immune reactions in response to tissue infection or injury. LÄS MER