Sökning: "5-LO"
Visar resultat 6 - 10 av 22 avhandlingar innehållade ordet 5-LO.
6. Biosynthesis and biological role of leukotrienes in B lymphocytes
Sammanfattning : Leukotrienes (LT) are potent lipid mediators, synthesized from arachidonic acid (AA) upon cell activation. The essential enzyme for leukotriene biosynthesis is 5-lipoxygenase (5-LO), converting AA, through a two step process to LTA4. The activity of 5-LO is dependent on 5-lipoxygenase activating protein (FLAP). LÄS MER
7. Leukotriene C4 synthase : studies on oligomerization and subcellular localization
Sammanfattning : Leukotrienes (LTs) are polyunsaturated fatty acid derivatives formed by oxygenation of arachidonic acid via the 5-lipoxygenase (5-LO) pathway. Upon activation of inflammatory cells 5-LO is translocated to the nuclear envelope where it converts arachidonic acid to the unstable epoxide LTA4. LÄS MER
8. New molecular markers in mantle cell lymphoma : studies of cannabinoid receptors, 5-lipoxygenase and SOX11
Sammanfattning : Mantle cell lymphoma (MCL) is a malignant B-cell lymphoma that accounts for 5-10% of all lymphomas and tends to occur in older adults with a higher incidence in males. The genetic hallmark of this neoplasm is the t(11;14) translocation which results in overexpression of nuclear cyclin D1. LÄS MER
9. Studies on the regulation of leukotriene biosynthesis in antigen presenting cells
Sammanfattning : Leukotrienes (LTs) are pro-inflammatory lipid mediators with important roles in host de- fense and inflammatory disease. Leukotriene B4 (LTB4) is a potent chemoattractant for neutrophils and contributes to bacterial killing, while the cysteinyl leukotrienes (LTC4, LTD4 and LTE4) elicit increased vascular permeability, bronchoconstriction, eosinophil trafficking and mucus secretion. LÄS MER
10. Leukotrienes and leukotriene receptors : potential roles in cardiovascular diseases
Sammanfattning : Leukotrienes (LTs) are a family of lipid mediators that are involved in host defense and inflammatory responses. They are synthesized from arachidonic acid through the 5-lipoxygenase (5-LO) pathway, and are divided into two classes, the classical chemoattractant leukotriene B4 (LTB4), and spasmogenic cysteinyl leukotrienes (cys-Us) including LTC4, LTD4 and LTE4. LÄS MER