Sökning: "5-LO"

Visar resultat 11 - 15 av 22 avhandlingar innehållade ordet 5-LO.

  1. 11. Non-invasive analysis of leukotrienes as biomarkers of airway inflammation : method development and clinical applications

    Författare :Flora Gaber; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Airway inflammation; aspirin-intolerant asthma; biomarker; exhaled breath condensate; FENO; induced sputum; leukotrienes; 5-lipoxygenase; non-invasive analysis; saliva;

    Sammanfattning : Asthma and chronic obstructive pulmonary disease (COPD) are two common diseases characterized by chronic airway inflammation, but the inflammation in asthma is different from the one in COPD. In addition, asthma is a heterogeneous disease presenting with many different phenotypes (e.g. LÄS MER

  3. 12. Studies on leukotriene B4 and alarmins in inflammatory responses

    Författare :Min Wan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Leukotriene B4 (LTB4) is a potent proinflammatory lipid mediator that is involved in host defense and inflammatory diseases, such as atherosclerosis. LL-37 and heparin binding protein (HBP) are cationic antimicrobial polypeptides, which belong to the alarmin family known to promote innate and adaptive immune reactions in response to tissue infection or injury. LÄS MER

  4. 13. Identification of inflammatory genes involved in the pathogenesis of human and experimental atherosclerosis

    Författare :Hanna E Agardh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Atherosclerosis is a chronic systemic inflammatory disease of large and medium sized arteries, developing slowly and silently over decades. The disease is usually not apparent until occurrence of a sudden clinical symptom, such as myocardial infarction (MI) or stroke. LÄS MER

  5. 14. Role of inflammatory and mitochondria genes in adipose tissue and obesity

    Författare :Maria Kaaman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Obesity is rapidly increasing in prevalence around the world together with its complications such as dyslipidemia, cardiovascular disease (CVD) and insulin resistance, which eventually may lead to type 2 diabetes (T2DM). The excess of adipose tissue, the hallmark of obesity, led us to study the adipose tissue as a contributor to obesity and insulin resistance. LÄS MER

  7. 15. Eicosanoids in cancer : new therapeutic targets in neuroblastoma

    Författare :Agnes Rasmuson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer is one of the most common causes of death for both children and adults in developed countries. Neuroblastoma is a cancer of the sympathetic nervous system that affects infants and young children. Neuroblastoma tumors are the most common solid extracranial tumors in children and are also the most deadly. LÄS MER