Sökning: "5-HT2A serotonin receptor"

Visar resultat 11 - 15 av 23 avhandlingar innehållade orden 5-HT2A serotonin receptor.

  1. 11. Novel insights into the role of serotonin in control of β-cell fuction

    Författare :Hedvig Bennet; Celiaki och diabetes; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Inadequate insulin secretion is a central component in the development of Diabetes Mellitus, resulting from reduced pancreatic β-cell mass, as well as diminished β-cell function. Islet produced 5-hydroxy tryptamine (5-HT) is suggested to regulate insulin secretion and β-cell mass in rodents during pregnancy and in metabolically challenged states. LÄS MER

  3. 12. Estrogen receptor gene activity within the brain and the relation to psychiatric disorders : mapping and function

    Författare :Marie Österlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :steroid hormone; ER system; in situ hybridization; rnRNA; ER serotonin; depression; affective disorders;

    Sammanfattning : Estrogens have for a long time been known to regulate neuroendocrine functions in the central nervous system (CNS), primarily related to reproduction. In recent years estrogens have been found to also modulate many other brain functions, for example mood and cognition. LÄS MER

  4. 13. Distribution of serotonin receptors and transporters in the human brain : implications for psychosis

    Författare :Katarina Varnäs; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :5-HT receptors; autoradiography; in situ hybridization histochemistry; psychotic disorders;

    Sammanfattning : The serotonin (5-HT) system is thought to be involved in different psychiatric disorders, including depression and anxiety disorders, and is a major target for the pharmacological treatment of these conditions. The involvement of the 5-HT system in psychosis has been suggested, as 5-HT receptor agonism is a common mechanism of different classes of hallucinogenic drugs and several antipsychotics are 5-HT receptor antagonists. LÄS MER

  5. 14. Positron emission tomography in serotonergic drug development

    Författare :Bengt Andrée; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :PET; 5-HT1A receptors; 5-HT2A receptors; D2 dopamine receptors; antidepressive drugs; antipsychotic drugs; pindolol; NAD-299; S 16924; ORG 5222; M100907; WAY; DWAY;

    Sammanfattning : The serotonin neurotransmission system has a central role in drug treatment of depression and anxiety and is also discussed in relation to treatment of schizophrenia. The benefits of presently available drugs are however limited by partial of poor response and side effects. LÄS MER

  7. 15. Suicide attempt and genes : psychiatric and genetic characteristics of suicide attempters

    Författare :Maj-Liz Persson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Suicide; Attempted; Mental disorders; Association; Genetic markers; Serotonin; Norepinephrine; Dopamine;

    Sammanfattning : Suicide affects an appreciable number of people in all societies. Finding genes that predispose to suicidal behavior may help to identify individuals at risk and an appropriate counseling and support can be extended to them. The studies of the present thesis focus on suicide attempt. LÄS MER