Sökning: "5-HT1A receptors"

Visar resultat 6 - 10 av 41 avhandlingar innehållade orden 5-HT1A receptors.

  1. 6. Positron emission tomography in serotonergic drug development

    Författare :Bengt Andrée; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :PET; 5-HT1A receptors; 5-HT2A receptors; D2 dopamine receptors; antidepressive drugs; antipsychotic drugs; pindolol; NAD-299; S 16924; ORG 5222; M100907; WAY; DWAY;

    Sammanfattning : The serotonin neurotransmission system has a central role in drug treatment of depression and anxiety and is also discussed in relation to treatment of schizophrenia. The benefits of presently available drugs are however limited by partial of poor response and side effects. LÄS MER

  3. 7. Galanin : a modulator of serotonin neurotransmission : relevance for depression

    Författare :Haleh Razani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :galanin; 5-HT1A receptors; 5-HT; 8-OH-DPAT; fluoxetine; robalzotan; passive avoidance; microdialysis; mRNA; KD values; Bmax values; depression;

    Sammanfattning : Galanin is widely distributed throughout the central nervous system with multiple and diverse biological roles. In the rat, galanin-like immunoreactivity is expressed in a population of5-hydroxytryptamine (5-HT, serotonin) neurons in the dorsal raphe (DR) with extensive projections to the forebrain areas e.g., hippocampus. LÄS MER

  4. 8. Development of positron emission tomography radioligands for the dopaminergic and serotonergic neurotransmission systems

    Författare :Camilla Lundkvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :PET; Radioligand; Dopamine transporter; Serotonin transporter; 5-HT1A receptor; 5-HT2A receptor;

    Sammanfattning : The dopaminergic and serotonergic neurotransmission systems are of central interest in relation to several neuropsychiatric disorders. The main objectives were to develop new suitable radioligands for positron emission tomography (PET) examinations of the dopamine transporter (DAT) as well as the serotonin 5-HT1A and 5-HT2A-receptors. LÄS MER

  5. 9. PET evaluation of central serotonergic neurotransmission in women

    Författare :Hristina Jovanovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :PET; serotonin; 5-HT1A receptor; 5-HTT; WAY100635; MADAM; premenstrual dysphoric disorder; borderline personality disorder; gonadal hormones;

    Sammanfattning : The serotonin (5-HT) system is of central interest in the patophysiology and treatment of several psychiatric disorders including depression, anxiety and suicide. In women, functioning of the 5-HT system is of particular importance since they have been found to suffer more often from 5-HT-associated disorders compared to men. LÄS MER

  7. 10. PET studies of the serotonin transporter in the human brain

    Författare :Johan Lundberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :positron emission tomography; MADAM; WAY 100635; 5-HTT; 5-HT1A receptors; receptor occupancy; major depressive disorder; citalopram; escitalopram;

    Sammanfattning : The serotonin (5-HT) system attracts considerable attention in research on the pathophysiology and drug treatment of neuropsychiatric disorders. The brain imaging technique Positron Emission Tomography (PET) allows for examination of neurotransmission systems in the human brain in vivo. LÄS MER