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Visar resultat 1 - 5 av 41 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Serotonergic receptor subtypes in learning and memory : focus on 5-HT1A, 5-HT1B and 5-HT2A receptors

   Författare :Maria Lüttgen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Serotonin; 5-HT1A receptor; 5-HT1B receptor; 5-HT2A receptor; acetylcholine; NMDA receptor; water maze; passive avoidance; septum; hippocampus; teaming; memory; immunohistochemistry; mRNA;

   Sammanfattning : The aim of this thesis was to study how serotonin (5-HT) receptor subtypes can influence hippocampus/amygdala-dependent teaming and memory using the water maze (WM) and the passive avoidance (PA) tasks in rodents, and to provide a cellular correlate to the behavioral results using histochemical methods. Glutamatergic neurons in the trisynaptic circuit of the hippocampus are believed to be important for spatial teaming and memory as well as synaptic plasticity. LÄS MER

3. 2. Modulation of acetylcholine release by serotonergic 5-HT1A and 5-HT1B receptors : a microdialysis study in the awake rat

   Författare :Xiao Jing Hu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Microdialysis; Acetylcholine; Serotonin; 5-HT1A receptor; 5-HT1B receptor; Frontal cortex; Ventral hippocampus;

   Sammanfattning : The aim of the thesis was to investigate the effects of the 5-HT1A receptor antagonist robalzotan (NAD-299) and the 5-HT1B receptor antagonist NAS-181 ((R)-(+)-2-(3-morpholinomethyl-2Hchromen-8-yl) oxymethyl-morpholine methanesulfonate) on cholinergic, glutamatergic and GABAergic neurotransmission in the rat brain in vivo. The extracellular levels of acetylcholine (ACh), glutamate (Glu) and GABA were monitored by microdialysis in the frontal cortex (FC) and ventral hippocampus (VHipp) in separate groups of awake rats. LÄS MER

4. 3. 5-HT1A receptor ligands with putative antidepressant activity : pharmacological studies in the rat

   Författare :Lotta Arborelius; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :antidepressants; citalopram; dopamine; dorsal raphe nucleus; electrophysiology; frontal cortex; 5-HT; A receptors; microdialysis; serotonin; rat;

   Sammanfattning : Several studies suggest that serotonin (5-hydroxytryptamine, 5-HT)IA receptor agonists possess antidepressant activity. Probably these agents exert their therapeutic effect through stimulation of postsynaptic 5-HT,A receptors. LÄS MER

5. 4. Development of radioligands for the serotonergic neurotransmission system for use in positron emission tomography

   Författare :Johan Sandell; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :PET; Radioligand; Brain; 5-HT1A receptor; serotonin transporter;

   Sammanfattning : The serotonergic system is implicated in several neuropsychiatric disorders, such as depression, anxiety and schizophrenia. Several hypotheses on the pathophysiology of these disorders are based on the pharmacology of serotonergic drugs. Selective serotonin reuptake inhibitors (SSRIs) are widely used for the treatment of depression and anxiety. LÄS MER

7. 5. Distribution of serotonin receptors and transporters in the human brain : implications for psychosis

   Författare :Katarina Varnäs; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :5-HT receptors; autoradiography; in situ hybridization histochemistry; psychotic disorders;

   Sammanfattning : The serotonin (5-HT) system is thought to be involved in different psychiatric disorders, including depression and anxiety disorders, and is a major target for the pharmacological treatment of these conditions. The involvement of the 5-HT system in psychosis has been suggested, as 5-HT receptor agonism is a common mechanism of different classes of hallucinogenic drugs and several antipsychotics are 5-HT receptor antagonists. LÄS MER