Sökning: "5-HT"

Visar resultat 6 - 10 av 98 avhandlingar innehållade ordet 5-HT.

  1. 6. Involvement of non-dopaminergic systems in L-DOPA-induced dyskinsia

    Författare :Daniella Rylander; Basala gangliernas patofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; Dyskinesia; L-DOPA; 6-OHDA rat model; MPTP monkey model; glutamate; serotonin; DA.; 5-HT;

    Sammanfattning : Parkinson's disease and L-DOPA-induced dyskinesia (LID) does not merely involve the dopamine (DA) system but also include non-dopaminergic systems such as glutamate and serotonin (5-HT). An aberrant glutamate transmission at the corticostriatal synapse, has been linked to LID. LÄS MER

  3. 7. Biomarkers in chronic and experimental human muscle pain

    Författare :Sofia Louca Jounger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :5-HT;

    Sammanfattning : The main aim of this thesis was to improve the knowledge ofthe peripheral mechanisms that may participate in the underlying pathophysiology of chronic temporomandibular disorders (TMD) myalgia i.e. pain that is experienced locally in the jaw muscles and has myofascial trigger points. LÄS MER

  4. 8. Cytokine induced airway hyperreactivity characterized in an in-vitro model of asthma

    Författare :Yaping Zhang; Klinisk och experimentell allergiforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; toxicology; Farmakologi; farmakognosi; MAPK; TNF-alpha; 5-HT; Respiratory system; Andningsorganen; Pharmacological sciences; pharmacognosy; pharmacy; interleukin-1beta; hyperresponsiveness; endothelin-1; airway; bradykinin; toxikologi; farmaci;

    Sammanfattning : Asthma is a chronic disorder of the lower airways, characterized by inflammation and hyperreactivity. Pro-inflammatory cytokines like tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) are known to play important roles in the pathogenesis, but our knowledge how these cytokines contribute to the development of airway hyperreactivity is limited. LÄS MER

  5. 9. Bioactive Compounds from the Marine Sponge Geodia barretti : Characterization, Antifouling Activity and Molecular Targets

    Författare :Martin Sjögren; Lars Bohlin; Per Jonsson; Anna-Karin Borg-Karlsson; Uppsala universitet; []
    Nyckelord :Pharmacognosy; Geodia barretti; barettin; secondary metabolites; settling inhibition; Balanus improvisus; analogs; 5-HT; Farmakognosi;

    Sammanfattning : The marine sponge Geodia barretti produces a range of secondary metabolites. Two of these compounds were isolated and elucidated guided by their ability to inhibit settlement of cypris larvae of the barnacle Balanus improvisus. LÄS MER

  7. 10. Modulatory effects and interactions of substance P, dopamine and 5-HT in a neuronal network

    Författare :Erik Svensson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Lamprey; spinal cord; neuromodulation; substance P; 5-HT; dopamine;

    Sammanfattning : The spinal neuronal network that generates the locomotor rhythm in lamprey contains excitatory and inhibitory interneurons, reticulospinal inputs from the brainstem, and motor neurons. In this thesis, I have studied how the spinal locomotor network cart be modulated by a tachykinin, dopamine and 5- HT that are co-localized in midline neurons situated below the central canal. LÄS MER