Sökning: "5-HT"

Visar resultat 11 - 15 av 98 avhandlingar innehållade ordet 5-HT.

  1. 11. On receptor changes in cerebral arteries after subarachnoid haemorrhage

    Författare :Jacob Hansen-Schwartz; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Pharmacological sciences; subarachnoid haemorrhage; reverse transcriptase polymerase chain reaction; in vitro pharmacology; organ culture; Endothelin receptors; 5-HT receptors;

    Sammanfattning : Overall the aim has been to characterise the in vitro upregulation of the 5-hydroxytryptamine 1B/1D (5-HT(1B/1D)) and endothelin (ET) receptors in the cerebral circulation as well as demonstrating phenotypic changes in a pathophysiological model mimicking subarachnoid haemorrhage. The first part describes receptor upregulation using organ culture of whole vessel segments from both rat and man. LÄS MER

  3. 12. 5-HT receptor-mediated modulation of glutamate transmission in the hippocampus and prefrontal cortex and its relation to cognition and depression

    Författare :Tiberiu Loredan Stan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Depression is a multifaceted disease which is marked by cognitive and emotional memory impairments. It is characterised by an imbalacement of serotonergic and glutamatergic system in brain areas such as hippocampus and prefontal cortex. LÄS MER

  4. 13. High-resolution Studies of mRNA Expression in Brain : A Search for Genes Differently Expressed in Schizophrenia

    Författare :Anja Castensson; Elena Jazin; Terence Speed; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; mRNA; gene expression; real-time RT-PCR; schizophrenia; 5-HT serotonin receptor 2C; brain; psychiatric genetics; Genetik; Clinical genetics; Klinisk genetik;

    Sammanfattning : Gene expression differences between patients and controls can be used to find susceptibility genes and drug targets for a disease. High-resolution strategies are required because the differences between the investigated groups may be small and numerous factors may affect the mRNA quantity. LÄS MER

  5. 14. Neuromolecular and behavioural profile of teleosts : - effects of boldness, agonistic behaviour and reproductive status

    Författare :Arshi Mustafa; Svante Winberg; Per Erik Olsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Histamine receptor 1 hrh1 ; histamine receptor 2 hrh2 ; histamine receptor 3 hrh3 ; boldness; personality; aggression; Histaminergic activity; Serotonergic activty 5-HIAA 5-HT ; Dopaminergic activty DOPAC DA ; spiegeldanio spd ; wild caught zebrafish; AB zebrafish; behaviour; brain.;

    Sammanfattning : This thesis investigates if boldness is reflected in the function of brain histaminergic system in zebrafish (Danio rerio). Moreover, behavioural differences in AB line, spiegeldanio (spd) line and wild caught strain of zebrafish have also been explored apart from the winner-loser effect in AB and spd fish. LÄS MER

  7. 15. Distribution of serotonin receptors and transporters in the human brain : implications for psychosis

    Författare :Katarina Varnäs; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :5-HT receptors; autoradiography; in situ hybridization histochemistry; psychotic disorders;

    Sammanfattning : The serotonin (5-HT) system is thought to be involved in different psychiatric disorders, including depression and anxiety disorders, and is a major target for the pharmacological treatment of these conditions. The involvement of the 5-HT system in psychosis has been suggested, as 5-HT receptor agonism is a common mechanism of different classes of hallucinogenic drugs and several antipsychotics are 5-HT receptor antagonists. LÄS MER