Sökning: "4G 5G polymorphism"
Visar resultat 1 - 5 av 10 avhandlingar innehållade orden 4G 5G polymorphism.
1. On the Tissue-type Plasminogen Activator (t-PA) -7,351C>T Enhancer Polymorphism. Importance for endothelial t-PA gene expression and arterial thrombotic disease
Sammanfattning : Local endothelial release of tissue-type plasminogen activator (t-PA) is an important thromboprotective mechanism. Earlier work by our group has identified a common single nucleotide polymorphism (SNP) at the t-PA locus (-7,351C>T), located within a GC-box in the retinoic acid (RA) and steroid hormone responsive t-PA enhancer. LÄS MER
2. Genetic aspects of stroke : association and linkage studies in a northern Swedish population
Sammanfattning : Stroke is a common, multifactorial cardiovascular disease. A stroke event is the result of traditional risk factors (i.e. hypertension, diabetes, smoking), environmental exposures and genetic factors in a complex interplay. LÄS MER
3. Plasminogen Activator Inhibitor 1 in Platelets - Studies of Synthesis, Activity, and Glycosylation Patterns
Sammanfattning : Plasminogen activator inhibitor 1 (PAI-1) is the main physiological inhibitor of tissue-type plasminogen activator. Thus PAI-1 plays an important role in decreasing the fibrinolytic activity in human blood. PAI-1 is present in high concentrations in platelets and also in low concentrations in plasma, but the source of plasma PAI-1 is not known. LÄS MER
4. Risk factors in ischemic stroke
Sammanfattning : Ischemic stroke is a complex disease in which environmental and genetic factors make about equal contributions to the etiology. However, knowledge regarding the molecular basis of the genetic influence and the impact of specific lifestyle factors is limited. LÄS MER
5. Regulation of plasminogen activator inhibitor-1 : role of triglyceride-rich lipoproteins, fatty acids and fibrate compounds
Sammanfattning : Impaired fibrinolytic function secondary to elevated plasma plasminogen activator inhibitor-1 (PAI-1) activity is associated with atherothrombotic disease, in particular coronary heart disease. Both environmental and genetic factors contribute to determine plasma PAI-1 levels and PAI-1 production in vivo. LÄS MER