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Visar resultat 1 - 5 av 10 avhandlingar som matchar ovanstående sökkriterier.
1. Hypoxia and Hypoxia-Inducible Factors in Normal and Malignant Breast Epithelium
Sammanfattning : Breast cancer treatment is based on tumor and patient related factors such as tumor stage, grade, hormonal status, HER2 status, patient age, and family history to name a few. It is today widely acknowledged that hypoxia and hypoxia-inducible factors (HIF:s) contribute to tumor progression. LÄS MER
2. Engraftment and tolerance induction in cellular therapy : focus on mesenchymal stromal cells
Sammanfattning : Different cell types have been employed in the search for a cellular therapy that is applicable for the treatment of heart failure. Remuscularization strategies using stem-cell-derived cardiomyocytes have been prone to arrhythmias. LÄS MER
3. Proteomics informed investigation of human hepatocytes and liver tissue
Sammanfattning : A successful drug needs to display beneficial absorption, distribution, metabolism, excretion and toxicity (ADME-Tox) profile. It is therefore important to investigate these properties during the drug discovery process. LÄS MER
4. Asymmetric Cellular Microenvironments
Sammanfattning : This thesis presents methods to combine 3D cell culture, microfluidics and gradients on a controlled cellular scale. 3D cultures in biological extracellular matrix gels or synthetic gels bridge the gap between organ-tissue cultures and traditional 2D cultures. LÄS MER
5. Fabrication advances of microvasculature models on-chip
Sammanfattning : Despite the technological advances of the last decades, drug development remains a lengthy and costly process with uncertainties still associated with the poor predictive power of the in vitro and animal models. To address this limitation, microphysiological systems have been introduced in an attempt to increase the biological relevance of in vitro devices. LÄS MER