Sökning: "3D-cultures"

Hittade 5 avhandlingar innehållade ordet 3D-cultures.

  1. 1. Hypoxia and Hypoxia-Inducible Factors in Normal and Malignant Breast Epithelium

    Detta är en avhandling från Department of Laboratory Medicine, Lund University

    Författare :Karolina Helczynska; Lunds universitet.; Lund University.; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Differentiation; Hypoxia; Breast cancer; Breast; HiF-1; HiF-2; 3D-cultures; prognosis;

    Sammanfattning : Breast cancer treatment is based on tumor and patient related factors such as tumor stage, grade, hormonal status, HER2 status, patient age, and family history to name a few. It is today widely acknowledged that hypoxia and hypoxia-inducible factors (HIF:s) contribute to tumor progression. LÄS MER

  2. 2. Engraftment and tolerance induction in cellular therapy : focus on mesenchymal stromal cells

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Molecular Medicine and Surgery

    Författare :Karin Ljung; Karolinska Institutet.; Karolinska Institutet.; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Different cell types have been employed in the search for a cellular therapy that is applicable for the treatment of heart failure. Remuscularization strategies using stem-cell-derived cardiomyocytes have been prone to arrhythmias. LÄS MER

  3. 3. Asymmetric Cellular Microenvironments

    Detta är en avhandling från Stockholm : KTH

    Författare :Susanna Rydholm; KTH.; [2008]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES Physics; NATURVETENSKAP Fysik;

    Sammanfattning : This thesis presents methods to combine 3D cell culture, microfluidics and gradients on a controlled cellular scale. 3D cultures in biological extracellular matrix gels or synthetic gels bridge the gap between organ-tissue cultures and traditional 2D cultures. LÄS MER

  4. 4. The reactive stroma in pancreatic diseases

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Clinical Science, Intervention and Technology

    Författare :Jessica Norberg; Karolinska Institutet.; Karolinska Institutet.; [2019]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Stroma, or activated connective tissue, is a key component in both pancreatitis and pancreatic tumors. Acute pancreatitis (AP) is an inflammation of the pancreas which ranges from mild and local to systemic with severe complications and high mortality. LÄS MER

  5. 5. Hypoxia-inducible factor-1 (HIF-1) in pancreatic cancer cell aggressiveness and therapeutic resistance and the potential role for pancreatic endocrine cells in islet transplantation

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Clinical Science, Intervention and Technology

    Författare :Xiaohui Jia; Karolinska Institutet.; Karolinska Institutet.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Tissue hypoxia results from an inadequate supply of oxygen (O2) that compromises biologic functions in various tissues, including both normal and malignant. It is known that a heterodimeric transcription factor hypoxia-inducible factor-1 (HIF-1) mainly mediates this critical adaptation. LÄS MER