Sökning: "3D cell culture"

Visar resultat 21 - 25 av 77 avhandlingar innehållade orden 3D cell culture.

  1. 21. Intervertebral disc regeneration. Studies on stem cell niches and cell transplantation

    Författare :Helena Barreto Henriksson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intervertebral disc stem cells degenerative disc cell transplantation stem cell niches disc degeneration mesenchymal stem cells cell therapy;

    Sammanfattning : Abstract Intervertebral disc regeneration Studies on stem cell niches and cell transplantation Helena Barreto Henriksson Gothenburg 2010 Low back pain is a common condition in the Western world and disc degeneration (DD) is considered a major cause. DD is characterized by dysfunctional cells and decreased matrix production. LÄS MER

  3. 22. Patient-derived scaffolds as a 3D model for breast cancer

    Författare :Anna Gustafsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; patient-derived scaffolds; cancer microenvironment; 3D model; cancer stem cells; drug testing;

    Sammanfattning : Breast cancer is the most common cancer form in women worldwide. Many patients will have recurrent disease and more efficient targeted therapies are needed. The tumor microenvironment is a heterogenous complex mix of cells and components influencing critical cancer processes including progression, signaling and invasion. LÄS MER

  4. 23. Proteomics informed investigation of human hepatocytes and liver tissue

    Författare :Niklas Handin; Per Artursson; Peter Nygren; Tobias Sjöblom; Mårten Fryknäs; Pieter Annaert; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human; liver; hepatocytes; proteomics; cellular stress; apoptosis; hepatotoxicity; 3D culture; spheroid; drug metabolism; drug toxicity; drug transport; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : A successful drug needs to display beneficial absorption, distribution, metabolism, excretion and toxicity (ADME-Tox) profile. It is therefore important to investigate these properties during the drug discovery process. LÄS MER

  5. 24. Modular Enzyme-Responsive Polysaccharide-Based Hydrogels for Biofabrication

    Författare :Sajjad Naeimipour; Daniel Aili; Robert Selegård; Alireza Dolatshahi-Pirouz; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; 3D cell-culture; Bioprinting; Alginate; Hyaluronan; Cancer model;

    Sammanfattning : Engineered human tissue and disease models can decrease the cost and time of developing new drugs and treatments, facilitate personalized medicine, and eliminate the need for animal models that poorly represent the human body and are ethically problematic. However, the current conventional cell expansion methods using 2D culture flasks cannot enable the development of such complex multi-cellular 3D models. LÄS MER

  7. 25. Ethanol-mediated effects on astroglial cells in primary culture. With a focus on acute changes in intracellular Ca2+, cell volume, actin filaments, and gap junction coupling

    Författare :Louise Adermark; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; astrocyte; BaCl2; cell swelling; fura-2; furosemide; ouabain; scrape loading; volume estimation;

    Sammanfattning : The astroglial cells are abundant in the central nervous system (CNS), where they control and regulate the homeostasis of the extracellular milieu. A change in astroglial cell volume, mediated through activation of neuroactive substances or changes in osmolarity, leads to changes in the size and geometry of the extracellular space volume, which could affect the diffusion and concentration of neuroactive substances. LÄS MER