Sökning: "3D cell culture"

Visar resultat 11 - 15 av 77 avhandlingar innehållade orden 3D cell culture.

  1. 11. Role of the co-transcriptional regulators Yap/Taz in the normal and fibrotic lung epithelia

    Författare :Hani N. Alsafadi; NanoLund: Centre for Nanoscience; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lung Epithelium; idiopathic pulmonary fibrosis IPF ; Developmental pathways; Hippo Signaling; Yap Taz; transcription factors; 3D culture models; ;

    Sammanfattning : Idiopathic pulmonary fibrosis (IPF) is a fatal disease that exhibits patterns of usual interstitial pneumonia with honeycombing. IPF is characterized by damaged distal lung epithelium with excessive tissue scarring and extracellular matrix remodeling. The etiology of IPF is unknown and current therapies cannot end or reverse disease progression. LÄS MER

  3. 12. Bioengineering and Cell-derived Strategies for Salivary Gland Regeneration

    Författare :Jiao DONG; Lungbioengineering och regeneration; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular vesicles; precision-cut tissue slices; histology scoring; sustainable histology; salivary gland; human dental pulp stem cells; extracellulära vesiklar; stamceller från mänsklig tandmassa; precisionsskurna vävnadsskivor; Spottkörtel; hållbar histologi och histologipoäng;

    Sammanfattning : Xerostomia (dry mouth symptoms) is a group of incurable debilitating conditions of salivary glands caused by aging, radiation/chemical exposure, or aberrant inflammation in the salivary glands. During this PhD thesis, we aimed to evaluate whether cell-derived strategies (e.g. LÄS MER

  4. 13. Ultrasound-assisted Interactions of Natural Killer Cells with Cancer Cells and Solid Tumors

    Författare :Athanasia Christakou; Martin Wiklund; Sabeth Verpoorte; KTH; []
    Nyckelord :Natural killer cell; cytotoxicity; heterogeneity; multiwell microchip; biocompatibility; ultrasonic cell manipulation; 3D cell culture; solid tumor; spheroid; high-resolution imaging; Biologisk fysik; Biological Physics;

    Sammanfattning : In this Thesis, we have developed a microtechnology-based method for culturing and visualizing high numbers of individual cells and cell-cell interactions over extended periods of time. The foundation of the device is a silicon-glass multiwell microplate (also referred as microchip) directly compatible with fluorescence microscopy. LÄS MER

  5. 14. Organic Electronics and Microphysiological Systems to Interface, Monitor, and Model Biology

    Författare :Sebastian Buchmann; Anna Herland; Erica Zeglio; Agneta Richter-Dahlfors; Maria Asplund; KTH; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; organic bioelectronics; organic electrochemical transistors; conjugated polymers; microphysiological systems; in vitro cell models; Organisk bioelektronik; organiska elektrokemiska transistorer; Konjugerade polymerer; Mikrofysiologiska system; in vitro-modeller; Medicinsk teknologi; Medical Technology;

    Sammanfattning : Biological processes in the human body are regulated through complex and precise arrangements of cell structures and their interactions. In vivo models serve as the most accurate choice for biological studies to understand these processes. However, they are costly, time-consuming, and raise ethical issues. LÄS MER

  7. 15. In vitro wound healing characteristics of amelogenins

    Författare :Sofia Almqvist; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amelogenins; extracellular matrix; cell culture; macrophage; fibroblast; endothelial cell; integrin; cytokine; inflammation; wound healing tissue repair;

    Sammanfattning : Wound healing involves the co-ordinated actions of several cell types, soluble cell mediators and extracellular matrix (ECM). This research project intended to investigate the role of certain ECM proteins in different processes during tissue repair by studying the interaction between dermal cells and ECM. LÄS MER