Sökning: "27-hydroxycholesterol"

Visar resultat 11 - 15 av 21 avhandlingar innehållade ordet 27-hydroxycholesterol.

  1. 11. Characterisation of autophagy pathways in atherosclerosis

    Författare :Peter Saliba Gustafsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Atherosclerosis is an inflammatory disease of large to intermediate-sized arteries, characterised by retention of modified low-density lipoprotein within the vessel wall; this evokes an inflammatory response. Low-density lipoprotein carries lipids such as fatty acids, triglycerides and cholesterol, from the liver to peripheral tissues. LÄS MER

  3. 12. Studies on oxysterols : origins, properties and roles

    Författare :Steve Meaney; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cytochrome P-450; oxysterols; cholesterol homeostasis;

    Sammanfattning : Oxysterols are derivatives of cholesterol present at low concentrations in a variety of physiological compartments. The major oxysterols in human circulation are formed from pools of cholesterol that may be distinguished by their miscibility with plasma cholesterol. LÄS MER

  4. 13. Biomarkers in Multiple Sclerosis - Monitoring disease activity and treatment afficacy

    Författare :Lenka Nováková Nyrén; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biomarkers; multiple sclerosis; neurodegeneration; inflammation; treatment;

    Sammanfattning : The pathophysiology of multiple sclerosis (MS) is complex with the presence of inflammation and neurodegeneration in all stages of the disease. The disease course, treatment response and outcome are highly variable in MS. LÄS MER

  5. 14. From cholesterol to oxidative stress in Alzheimer's disease : a wide perspective on a multifactorial disease

    Författare :Susanne Akterin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epidemiological studies have provided evidence that high cholesterol levels in midlife and lack of antioxidants could render people more susceptible to develop AD. The aim of this thesis project was to get a more profound view of how cholesterol and oxidative stress could modify the development of Alzheimer s disease (AD) on the molecular level, by studying mechanisms of signal transduction. LÄS MER

  7. 15. Statin treatment and beta-Amyloid Production in Patients with Alzheimer s Disease

    Författare :Kina Höglund; Göteborgs universitet; []
    Nyckelord :Alzheimer s disease; amyloid precursor protein; beta-amyloid; cholesterol; statins; CSF;

    Sammanfattning : Alzheimer s disease (AD) is a progressive neurodegenerative disorder pathologically characterized by neurofibrillary tangles and amyloid plaques. According to the amyloid cascade hypothesis, the increased production of beta-amyloid (Abeta), derived form the amyloid precursor protein (APP), and its aggregation into plaques are key pathological events, driving neurodegeneration in AD. LÄS MER