Sökning: "27-hydroxycholesterol"

Visar resultat 1 - 5 av 19 avhandlingar innehållade ordet 27-hydroxycholesterol.

  1. 1. Deciphering the role of 27-hydroxycholesterol in neurodegeneration

    Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of Neurobiology, Care Sciences and Society

    Författare :Muhammad Al Mustafa Ismail; Karolinska Institutet.; Karolinska Institutet.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cholesterol is constantly attributed to neurodegenerative diseases including Alzheimer’s disease (AD). This is due to the association of high blood cholesterol and the consequences of cholesterol metabolism in these conditions. LÄS MER

  2. 2. Brain cholesterol metabolism : A study of mouse and man

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Laboratory Medicine

    Författare :Maura Heverin; Karolinska Institutet.; Karolinska Institutet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s Disease; 27-hydroxycholesterol; CYP46A1; cholesterol homeostasis.;

    Sammanfattning : The brain is the most cholesterol rich organ in the body and contains about one quarter of the body's total cholesterol. How this cholesterol and its metabolism affects the complex brain under normal and pathological conditions has been the focus of intense research in recent years due to its possible association with the development or progression of neurodegeneration. LÄS MER

  3. 3. Implications of cholesterol and cholesterol-lowering therapy in Alzheimer s disease

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Neurobiology, Care Sciences and Society

    Författare :Daniel Famer; Karolinska Institutet.; Karolinska Institutet.; [2007]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; dietary cholesterol; rosuvastatin; apolipoprotein E; alpha-secretase; beta-secretase; alpha- beta-secretase ratio; soluble APPalpha; gliosis; microglial load; interleukin-6; caspase-3; body weight gain; lifestyle-preventive strategy; 24 S -hydroxycholesterol; 27-hydroxycholesterol;

    Sammanfattning : BACKGROUND: Alzheimer s disease (AD) is a severe neurodegenerative disease that mainly afflicts elderly persons, with a characteristic progressive decline of cognitive functions and dementia. It is believed that the majority of all AD patients are affected by the sporadic form, thus caused by the combined effects of several risk factors, such as elevated cholesterol levels in midlife and deficiencies in the lipoprotein transporters apolipoprotein E (ApoE). LÄS MER

  4. 4. Cytochrome P450 Enzymes in the Metabolism of Cholesterol and Cholesterol Derivatives

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Maria Norlin; Uppsala universitet.; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; PHARMACY Biopharmacy; FARMACI Biofarmaci; farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Sammanfattning : Cholesterol is metabolized to a variety of important biological products in the body including bile acids and vitamin D. The present investigation is focused on enzymes that catalyze 7α-hydroxylation or 27-hydroxylation in the metabolism of cholesterol, oxysterols (side chain-hydroxylated derivatives of cholesterol) and vitamin D3. LÄS MER

  5. 5. On the possible use of oxysterols for the diagnosis and evaluation of patients with neurological and neurodegenerative diseases

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Laboratory Medicine

    Författare :Valerio Leoni; Karolinska Institutet.; Karolinska Institutet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple sclerosis; Alzheimer s disease; oxysterol; central nervous system; gas chromatography-mass spectrometry; blood brain barrier; cholesterol;

    Sammanfattning : Oxysterols are monooxygenated derivatives of cholesterol with a unique ability to pass lipophilic membranes and are involved in a number of elimination pathways for cholesterol. One of the major oxysterols in the circulation, 24S-hydroxycholesterol, is formed exclusively in the brain, mainly in neuronal cells. LÄS MER