Sökning: "20S proteasome"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden 20S proteasome.

  1. 1. Investigating the activation and regulation of the proteasome : an essential proteolytic complex

    Författare :Patrick Masson; Patrick Young; Marcus Groettrup; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Proteasome; PA28gamma; Transcriptional regulation; Drosophila; 26S; Molecular biology; Molekylärbiologi;

    Sammanfattning : The proteasome is a major non-lysosomal proteolytic complex present in eukaryotic cells and has a central role in regulating many protein levels. The complex has been shown to participate in various intracellular pathways including cell cycle regulation or quality control of newly synthesized proteins and many other key pathways. LÄS MER

  2. 2. Embryonic Stem Cells: Differentiation into Insulin Producing Cells and Elimination of Damaged Proteins

    Författare :Gabriella Brolén; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; oxidatively damaged proteins; diabetes; carbonyl; C-peptide; Medicine human and vertebrates ; insulin; human embryonic stem cell; 20S proteasome; AGE; Pdx1; proinsulin;

    Sammanfattning : This thesis includes two different parts: One focusing on how to induce human embryonic stem cells (hESCs) to differentiate into insulin producing cells by following the normal pancreatic development pathway. These cells have then the potential to be an unlimited source for diabetes regenerative medicine. LÄS MER

  3. 3. Studies of metazoan proteasome function and regulation

    Författare :Josefin Lundgren; Patrick Young; Michael Glickman; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; proteasome ubiquitin RNAi microarray; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Biological processes depend upon the structural and functional quality of the molecules that comprise living organisms. The integrity of molecules such as DNA, RNA, proteins, carbohydrates and lipids is crucial and the precise three-dimensional shape and the detailed chemistry of these molecules orchestrate the biochemical processes vital for life. LÄS MER

  4. 4. Proteasome Inhibitors against Cancer: Determining Biology and Finding Novel Compounds

    Författare :Arjan Mofers; Stig Linder; Padraig D´arcy; Sonia Lain; Linköpings universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cancer continues to be a tremendous burden on society in terms of loss of quality of life and life-years. The ubiquitin proteasome system (UPS), responsible for the bulk of protein turnover in the cell, is considered an attractive target in cancer therapy. LÄS MER

  5. 5. Inhibition of 19S proteasome deubiquitinases as a promising strategy in cancer therapy

    Författare :Magdalena Mazurkiewicz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : The ubiquitin proteasome system (UPS) is the main degradation system in the eukaryotic cell and it is involved in the regulation of many crucial cellular pathways; such as signal transduction, proliferation, DNA repair, cell death, and cell cycle regulation. In comparison to cells in healthy tissues, cancer cells proliferate faster and have increased protein synthesis rate; therefore in order to preserve cellular fitness they are more dependent on UPS than normal cells. LÄS MER