Sökning: "1400"

Visar resultat 1 - 5 av 708 avhandlingar innehållade ordet 1400.

  1. 1. Development and Application of Proximity Assays for Proteome Analysis in Medicine

    Författare :Felipe Marques Souza de Oliveira; Masood Kamali-Moghaddam; Ulf Landegren; Mats Gullberg; Janne Lehtiö; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Solid-phase proximity ligation assay; post-translational modifications; glycosylation; phosphorylation; Enzyme-linked immunosorbent assay; immunoassay and rolling circle amplification; Proximity Extension Assay; inflammation protein biomarkers; autoantibodies; autoimmune disease;

    Sammanfattning : Along with proteins, a myriad of different molecular biomarkers, such as post-translational modifications and autoantibodies, could be used in an attempt to improve disease detection and progression. In this thesis, I build on several iterations of the proximity ligation assay to develop and apply new adaptable methods to facilitate detection of proteins, autoantibodies and post-translational modifications. LÄS MER

  3. 2. Quasicrystal Approximants in the RE-Au-SM systems (RE = Gd, Tb, Ho, Yb; SM = Si, Ge) : Syntheses, structures and properties

    Författare :Girma Hailu Gebresenbut; Cesar Pay Gómez; Martin Sahlberg; Torbjörn Gustafsson; Alan I. Goldman; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Quasicrystal approximant; structure; physical property; Chemistry with specialization in Inorganic Chemistry; Kemi med inriktning mot oorganisk kemi; Physics with spec. in Atomic; Molecular and Condensed Matter Physics; Fysik med inriktning mot atom- molekyl- och kondenserande materiens fysik;

    Sammanfattning : In this study, new Tsai-type 1/1 quasicrystal approximants (ACs) in the RE-Au-SM systems (RE = Gd, Tb, Ho, Yb; SM = Si, Ge) were synthesized using high temperature synthesis techniques such as self-flux, arc-melting-annealing and novel arc-melting-self-flux methods. The syntheses not only provided appropriate samples for the intended structural and physical property measurements but could also be adapted to other systems, especially where crystal growth is a challenge. LÄS MER

  4. 3. Fuel Optimal Powertrain Control for Heavy Trucks Utilizing Look Ahead

    Författare :Maria Ivarsson; Lars Nielsen; Jan Åslund; Jan Wikander; Linköpings universitet; []
    Nyckelord :TECHNOLOGY; TEKNIKVETENSKAP;

    Sammanfattning : The road topography in highways affects the powertrain control of a heavy truck substantially since the engine power is low in relation to the vehicle weight. In large road gradients constant speed is not possible to keep, which would have been beneficial otherwise, and in some uphills shifting gears becomes inevitable. LÄS MER

  5. 4. Algorithmically Guided Information Visualization : Explorative Approaches for High Dimensional, Mixed and Categorical Data

    Författare :Sara Johansson Fernstad; Mikael Jern; Jimmy Johansson; Jane Shaw; Matthew O. Ward; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Information visualization; data mining; high dimensional data; categorical data; mixed data;

    Sammanfattning : Facilitated by the technological advances of the last decades, increasing amounts of complex data are being collected within fields such as biology, chemistry and social sciences. The major challenge today is not to gather data, but to extract useful information and gain insights from it. LÄS MER

  7. 5. Prognostic factors in renal cell carcinoma : evaluation of erythropoietin and its receptor, carbonic anhydrase IX, parathyroid hormone-related protein and osteopontin

    Författare :Karin Papworth; Torgny Rasmuson; Börje Ljungberg; Kjell Grankvist; Sten Nilsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Renal cell carcinoma; EPO; EPO-R; CA IX; PTHrP; OPN; prognosis; Oncology; Onkologi; onkologi; Oncology;

    Sammanfattning : A prognostic factor is a marker or a feature that can be used to estimate the risk of recurrence of disease, metastatic spread and clinical outcome. Despite intensive search for more sophisticated markers in renal cell carcinoma (RCC), few have added prognostic information to earlier described factors like stage of disease, nuclear grade, tumour type, and in metastatic disease; performance status, anaemia, hypercalcaemia and increased erythrocyte sedimentation. LÄS MER