Sökning: "β-lactam"

Visar resultat 16 - 20 av 26 avhandlingar innehållade ordet β-lactam.

1. 16. Studies on cell wall recycling and modification in Gram-negative bacteria

   Författare :Michael C. Gilmore; Felipe Cava; Peter A Lind; Teresa Frisan; Jean-François Collet; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Peptidoglycan recycling; bacterial cell wall; antibiotics; Agrobacterium tumefaciens; Escherichia coli; Legionella pneumophila; mikrobiologi; Microbiology; Biochemistry; biokemi;

   Sammanfattning : The bacterial cell wall is made from peptidoglycan (PG), a heteropolymer which forms a bag-like exoskeleton that envelopes the cell. PG is constantly remodelled during growth and division, and in response to environmental stimuli. LÄS MER

3. 17. Pharmacometrics to characterize innate immune response and antibacterial treatments

   Författare :Anders Thorsted; Lena E. Friberg; Elisabet I. Nielsen; Mats O. Karlsson; Gauri G. Rao; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; non-linear mixed effects modelling; modelling; pharmacokinetics; pharmacodynamics; pkpd; antibiotics; cefuroxime; piperacillin; phagocytes; lipopolysaccharide; endotoxin; porcine endotoxemia; challenge studies; sepsis; critically ill; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : The immune system protects the host against pathogens by distinguishing self from non-self. However, it is most-often disregarded in pharmacokinetic-pharmacodynamic (PKPD) characterization of (new and old) antibiotics. LÄS MER

4. 18. On community acquired infections requiring intensive care

   Författare :Magnus Brink; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intensive care; infection; acute bacterial meningitis; beta-lactam antibiotics; cerebrospinal fluid; polymerase chain reaction; immunochromatographic test; influenza A H1N1; pandemic; non-invasive ventilation; necrotizing soft-tissue infection; inter-hospital transfer;

   Sammanfattning : Acute bacterial meningitis (ABM), influenza, and necrotizing soft-tissue infections (NSTIs) are diseases that in a short period of time can progress to become life threatening. Individuals with severe forms of these infections must be treated in an intensive care unit were monitoring and support of failing organs improve the chances of survival. LÄS MER

5. 19. Long-term molecular epidemiology of extended-spectrum β-lactamase producing Escherichia coli in a low-endemic setting

   Författare :Anna Fagerström; Bo Söderquist; Paula Mölling; Martin Sundqvist; Katarina Persson; Linus Sandegren; Örebro universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Escherichia coli; extended-spectrum β-lactamase; whole genome sequencing; plasmids; hybrid assembly; environment; IncI1; ST131;

   Sammanfattning : Escherichia coli is a commensal inhabitant in the gastro-intestinal tract of humans and animals but it is also the most common bacterial species causing urinary tract infection, which ranges in severity from distal cystitis to urosepsis and septic shock. During the past decades, the prevalence of antibiotic resistant E. LÄS MER

7. 20. Multi-Resistance Plasmids : Fitness Costs, Dynamics and Evolution

   Författare :Fredrika Rajer; Linus Sandegren; Pål Jarle Johnsen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; multi-resistance plasmids; evolution; fitness cost; dynamics; escherichia coli; ESBL; gene amplification; β-lactamase inhibitor; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

   Sammanfattning : Antibiotic resistance is an escalating problem, not only due to less desirable treatment options and outcome, but also due to the economic burden to health care caused by resistant pathogens. Since the process of developing new antibiotics is slow, we need to carefully consider the usage of the antibiotics still available. LÄS MER