Sökning: "β-lactam"
Visar resultat 11 - 15 av 25 avhandlingar innehållade ordet β-lactam.
11. Development of phosphorus-containing metallo-β-lactamase inhibitors : Synthesis and binding studies by solution NMR and molecular docking
Sammanfattning : The rapidly growing bacterial resistance development is turning into one of the main challenges of the 21st century. Our antibiotics are becoming ineffective for the treatment of bacterial infections, and without successful action, simple infections, such as pneumonia or Septicemia, will soon carry a highly probable mortal prognosis. LÄS MER
12. Dynamics and Mechanisms of Adaptive Evolution in Bacteria
Sammanfattning : Determining the properties of mutations is fundamental to understanding the mechanisms of adaptive evolution. The major goal of this thesis is to investigate the mechanisms of bacterial adaptation to new environments using experimental evolution. LÄS MER
13. Cell wall remodeling proteins in Mycobacterium tuberculosis : structure, function and inhibition
Sammanfattning : The complex and peculiar cell wall architecture is vital for the survival of M. tuberculosis in the host and therefore an established target for several currently used drugs. LÄS MER
14. Invasive disease by Haemophilus influenzae in Sweden in the era of the H. influenzae type b vaccine
Sammanfattning : What is the current status of Haemophilus influenzae as an agent of invasive infection in Sweden? H. influenzae type b (Hib) used to be a common cause of meningitis, epiglottitis and severe sepsis in young children. LÄS MER
15. Plasmid mediated antibiotic resistance : with focus on extended spectrum β-lactamases (ESBL)
Sammanfattning : Enterobacteriaceae is a family of bacteria including Escherichia coli and Klebsiella pneumoniae that are common colonizers of the gastrointestinal tract. Extended spectrum β- lactamases (ESBL) are bacterial enzymes that degrade β-lactam antibiotics and thus make the bacteria resistant to β-lactam antibiotics. LÄS MER